الفهرس 
CHAPTER 1: ASTHMAOnly 14 pages are availabe for public view
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Abstract
Up until now, the assessment of inflammatory respiratory disorders in presence of different basic diseases such as Asthma was dependant on invasive methods such as bronchoscopy. However it is an invasive method and not easily performed specially in children. Urine examination for inflammatory markers of asthma seems a good, reliable and easily performed test specially in children.
In the present study we measured LTE4 in urine and T.s.IgE of asthmatic children to determine their value as non invasive markers of airway inflammation.
The present work included 88 children divided into 63 asthmatic children (group ΙΙ) and 25 healthy controls (group Ι) with age range of 3 – 14 years. All cases were subjected to full medical history and examination according to British thoracic society criteria 2012 with collection of a blood sample and a urine sample after a formal consent from all parents of children included in the study (within the first 24 hours of asthma exacerbation as regard to cases). Any cases outside the age range or had chronic systemic disease were excluded from the study.
The results of the present work showed that:
1. There was a highly significant increase in means of ULTE4 levels in cases when compared with controls.
2. There was a highly significant increase in means of T.s.IgE levels in cases than controls.
3. There was a highly significant correlation between asthma severity and both of ULTE4 and T.s.IgE levels in the cases (positive correlation).
4. We found highly significant positive correlation between ULTE4 and T.s.IgE among cases.
5. There was a difference in ULTE4 levels in relation to age and sex among cases but insignificant, also the same was detected in T.s.IgE level in relation to sex and age.
6. The level of T.s.IgE correlated well with asthma but did not correlate well with presence of atopy and showed a wide range among cases.