الفهرس 
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Abstract
Diabetes mellitus is one of the most common chronic diseases in nearly all countries, and continues to increase in numbers and significance, as changing lifestyles lead to reduced physical activity, and increased obesity. Some parameters may aid in the prevention and/or management of diabetes mellitus.
The statistics have proven that the diabetes prevalence in Egypt is on the rise, and there is a paper published in ”Diabetes research and clinical applications” journal stated that diabetes
prevalence in Egypt has become 10.4% in 2010 and is expected to reach to 12.8% in 2030.
The aim of the present work is to investigate the relationship between serum visfatin, some parameters of iron metabolism and insulin resistance in altered glucose tolerance patients and its relation to obesity.
The present study includes 80 subjects categorized into 5 groups as following: Group(I) includes 20 age and sex matched healthy subjects considered as control group.Group (II):
contains15 IGT patients, Group (III) includes 15 IDDM patients, Group (IVa) includes15 obese NIDDM patients and Group (IVb) contains 15 non obese NIDDM patients.Fasting and plasma pp glucose were estimated. HbA1c was determined to assess the degree of glycemic control, in addition to HOMA, HOMA β and QUICKI as tests for insulin resistance
and sensitivity. Lipid profile was also determined for all subjects. Serum ferritin was considered as an acute phase protein. Iron overload was evaluated by sTFR and sTFR/log ferritin. Serum visfatin may be considered as proinflammatory
adipokine, Also serum TNF-α was measured to evaluate low grade inflammation.
The results can be summarized as follows:
(1) Serum visfatin, ferritin, TNF-α and Triacylglycerol levels were significantly elevated in all IGT and diabetic patients compared to control group.
(2) Serum sTFR showed a highly significant decrease (p<0.05and p<0.01) in IDDM and non obese NIDDM patients with respect to the control group.
(3) Serum sTFR/ Log ferritin showed a highly significant decrease (p<0.05and p<0.01) in obese and non obese NIDDM patients compared to the control group.(4) HOMA showed a highly significant elevation (p<0.05 and
p<0.001) in IGT, obese and non obese NIDDM patients when compared to the control group.
(5) QUICKI showed a highly significant decrease (p<0.001) in IGT, obese and non obese NIDDM patients when compared to control group.
(6) HOMA β and HDL-C showed a highly significant decrease (p<0.01 and p<0.001) in IGT, IDDM, obese and non obese NIDDM patients when compared to the control group.
(7) Total cholesterol and LDL-C showed a highly significant elevation (p<0.001 and p<0.05) in obese and non obese NIDDM patients when compared to the control group.
As a conclusion, serum visfatin is correlated to some parameters of iron metabolism as ferritin and sTFR/log ferritin in type I diabetic patients and sTFR in obese type II patients.
Visfatin is also correlated with FPG in IGT group. So visfatin may be increased due to hyperglycemia itself and at the same time it may induce the progression of inflammatory condition
and complications.