الفهرس 
PathophysiologyOnly 14 pages are availabe for public view
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Abstract
Diabetes is a major public health problem that is becoming more prevalent
worldwide.DN is one of its frequent and costly complications and is usually related to
the duration and severity of hyperglycemia. Epidemiology of DN is still unclear
because of the multiple diagnostic criteria, inability of many physician to identify the
disease and poor methodology to evaluate the patients. DSP is the most common form
of DN. Pathogenesis of DN is still poorly understood. Hypothesis such as increased
polyol pathway flux; increase hexosamine pathway flux, advanced glycation end
products formation, activation of PKC, oxidative stress, PARP activation,
inflammation, and decreased neurotrophines are all suggested to play a major role in
that development of DN. There are many animal models of DN, which are useful to
investigate the pathogenesis of neuropathy and to evaluate different lines of therapy