الفهرس 
Review of the Literature
Thyroid Development and PhysiologyOnly 14 pages are availabe for public view
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Abstract
The screening of newborn children for metabolic and endocrinal disorders is one of the marvelous successes of the health service. This study aimed to evaluate the indicators of congenital hypothyroidism (CH) screening program in Fayoum in terms of coverage, effectiveness of detecting and managing the cases. A record review was conducted at the Fayoum health insurance hospital and data from Fayoum Health Directorate during the period from October 2002 to December 2012 to evaluate indicators of the program.
During the study period among the 825737 babies who underwent the screening test, 1849 neonates of them were recalled for confirmatory tests. Thus, the recall rate in our study was estimated as 0.2%. The mean age of the recalled neonates was 12.6 ± 10 days. The incidence of CH was calculated as 1: 2064 screened newborns during this period (2002-2012).
The incidence of CH was calculated as 1: 2064 screened newborns during this period (2002-2012).The newborn screening test (1st dry sample) was performed on the 3rd -7th day of life in 358 (89.5%) of the babies diagnosed with CH, 31 babies (7.7%) early in first 2 days, and 11 babies (2.8%) had their tests after the 7th day due to intercurrences at birth. The mean TSH levels obtained from heel-prick blood samples (1st dry sample) was 85 ±74 mIU/L. The mean serum TSH and T4 levels of neonates diagnosed with hypothyroidism were 86.1 ± 26.6 μIU/mL and 7.3 ± 5.7 ng/dL respectively. Of the 400 babies diagnosed with CH, 189 (47.2 %) were females, 211 (52.8%) were males, representing a Female/Male ratio of 1:1.1. Mean age at confirmation (venous sample) was 14 days ±10 (range from 5 to 106). Once the diagnosis was confirmed, therapy was started between day 6 and 113 after birth. In 259 primarily diagnosed CH patients through the neonatal screening Program from October 2002 to December 2009, 55 patients proved to have transient hypothyroidism (21.7%) and 204 patients with permanent hypothyroidism (78.3%).