الفهرس 
Hepatocellular CarcinomaOnly 14 pages are availabe for public view
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Abstract
Hepatocellular carcinoma (HCC) is a primary malignancy of the hepatocyte, generally leading to death within 6-20 months. It is the fifth most common cancer worldwide and the third most common cause of cancer mortality.
Although the main risk factors for HCC are HCV, hepatitis B virus (HBV) and chronic alcohol abuse, at least 25% of HCC cases do not have any known etiology, suggesting that further risk factors could be responsible for the increasing incidence of HCC. Diabetes mellitus has recently been proposed as a risk factor for HCC.
This study was carried out on 300 patients divided into three groups (100 patients with HCC, 100 with liver cirrhosis and 100 patients control). They were recruited from Internal Medicine Department and Hepatology outpatient clinic in Ain Shams University Hospitals in the period from May 2010 to February 2011.
The aim of this study was to assess Diabetes mellitus as a risk factor for hepatocellular carcinoma in Egyptian patients.
All the patients included in our study were subjected to full history taking and clinical examination, laboratory investigation, abdominal ultra sound and spiral triphasic CT.
Our study showed that HCC is more in males than in females. Their main age was 55 years.
In our study, smoking is considered a risk factor for HCC as it was higher in HCC than in liver cirrhosis and control patients.
BMI was higher in patients with liver cirrhosis than controls. So, overweight can be a cause of progression of the process of cirrhosis. While BMI was lower in HCC than in liver cirrhosis.
HCC was associated with higher ALT, AST, ALP and AFP level than in liver cirrhosis.
As expected, HBV and HCV were associated with HCC. HBV infection was higher in HCC than in liver cirrhosis and control patients.
By comparison between the three groups, our study suggested that DM is not adequate to increase the risk of hepatocellular carcinoma in Egyptian patients in the absence of concomitant viral hepatitis or liver disease. Whereas increased the duration of DM may be associated with progression of already existence HCC.