الفهرس 
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Abstract
The present work aims to study and evaluate NSE as predictor and prognostic marker of intraventricular / periventricular hemorrhage in preterm infants.
This case control study was conducted on 58 neonates, 30 preterm neonates and 28 full term neonates. 8 of 30 preterm infants (26.6%) got IVH while none of 28 full term infants got IVH. preterm infants with IVH, their gestational age ranged from 28-33 weeks, birth weight ranged from 500-2300gm, 87.5% of them were males, 62.5% of which delivered vaginally and none of which was the first baby of birth.
preterm infants without IVH were 22 infants, their gestational age ranged from 28-35 weeks, their birth weight ranged from 600-2600gm.
A thorough history was taken (prenatal, natal, postnatal).The infants were subjected to apgar score at 1 and 5 minutes, assessment of gestational age through analysis of maternal dates and Ballard scores, thorough complete clinical examination including cardiac, chest, abdominal and neurological, laboratory investigation including CBC, CRp and laboratory evaluation of NSE in cord blood was performed by ELISA technique and neonatal cranial ultrasound that done at 1,3,7 postnatal days.
Serum NSE level was statistically significant higher in preterm infants (mean ± SD 12.63 ±7.54 µg/L) compared to full term infants (mean ± SD 6.11 ± 4.54 µg/L), Z= -3.408, p <0.01.
Male sex may be more liable to birth complications as pIVH than female sex.
Statistically significant higher serum NSE was found in preterm infants with IVH (mean ± SD 21.01±3.13) compared to infants without IVH (mean± SD 9.58 ± 6.23µg/L), Z = -3.82, p <0.001.
Roc curve in the present study showed that cord blood NSE has 99.05 % specificity and 87.5 % sensitivity to predict IVH at cut off value of 18.8µg/L.
In conclusion:
The increasing level of serum NSE in preterm infants suggests that it is an early preclinical non invasive predictive marker for the occurrence of intraventricular hemorrhage in preterm infants.
Serum cord blood NSE has 99.05 % specificity and 87.5 % sensitivity to predict IVH at cut off value of 18.8µg/L.