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Abstract This study was conducted to evaluate the histopathological and the histochemical effects of pulpotec in comparison with calcium hydroxide on rabbit pulp tissue following pulpotomy .The study was done on 30 rabbits, one tooth in each rabbit was pulpotomized . 15 teeth were pulpotomized with calcium hydroxide(control group) and the other teeth were pulpotomized with pulpotec(exipermental group) and after one, two, three months follow up periods 5 rabbits from each group were sacrified and the teeth were obtained and prepared for histopathological examination(H&E stain) and histochemical evaluation(Alcian blue and Trichrome stains) Histopathological evaluation of calcium hydroxide (control group) in the first month showed a necrotic zone beneath the applied material followed by a partially formed dentin bridge accompanied by a slight inflammation limted to the exposure site in the majority of specimens . In the second month, the inflammatory process did not change aggressively and revealed slight to moderate inflammation involving the coronal one third of the pulp in addition to a zone of necrosis beneath the exposed area and a completely formed dentin bridge were detected in most of the specimens.In the third month the inflammatory response progressed to be moderate to affect the coronal and the middle two thirds(except in one specimen that revealed extensive inflammatory reaction) with area of necrosis beneath the exposed area followed by a more thicker completely formed dentin bridge were detected in most of the. |