الفهرس 
Pregnancy induced hypertensionOnly 14 pages are availabe for public view
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Abstract
The aim of our study was to determine the accuracy of uterine artery Doppler and serum TNF-α measurement between 11th and 14th week of pregnancy in predicting the development of gestational hypertension.
Prospective study that included 100 women between 11th to 14th weeks gestation. Doppler ultrasound was performed to measure the mean pulsatility index of the uterine arteries and blood samples were collected to measure serum TNF-α level. Follow up was done throughout pregnancy till delivery.
Six women developed gestational hypertension, eleven women developed preeclampsia and were considered cases while 83 women remained normotensive and were considered controls. There were no statistically significant differences between the two groups as regard maternal age, weight, height or BMI.
The mean PI of the right and the left uterine arteries were higher in women who developed gestational hypertension and preeclampsia than in normotensive women the differences were statistically significant.
The best cutoff value of the mean uterine artery pulatality index was 1.9 and at this value we have 99% sensitivity, 87% specificity, 90% positive predictive value (PPV), 99% Negative predictive value (NPV). Best cutoff value of serum TNF- α was 108 pg/mL which gives 83% sensitivity, 60% specificity, 67% PPV and 89%NPV in case of gestational hypertension.
The best cutoff value of the mean uterine artery pulatality index was 1.9 and at this value we have 100% sensitivity, 95% specificity, 97% positive predictive value (PPV), 100% Negative predictive value (NPV). Best cutoff value of serum TNF- α was 157 pg/mL which gives 100% sensitivity, 99% specificity, 99% PPV and 100%NPV in case of preeclampsia