الفهرس 
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Abstract
In this study, salinomycin (60 ppm feed), diclazuril (1 ppm feed) and their combination (30 ppm + 0.5 ppm) were given to non-infected and coccidia infected chickens for 6 successive days. Two blood samples were collected at one day, one, two and three weeks post drug administration. The first blood sample was used for the haernatological study, whereas, the second blood sample was used for separation of’serum for estimating some liver and kidney functions, total proteins, Ca2~& phosphorous. Samples from intestine, liver & kidneys were collected for the histopathological studies. Samples from the droppings at the various periods were examined for counting coccidia oocysts to evaluate the efficacy of the test drugs. Birds were also weighed at the different period for studying the effect of the test drugs on body weight and weight gain. Results are summarized as follows: A- Oocyst count: The test drugs and their combination caused a gradual decrease in the count of coccidia oocysts shedded in the droppings of the infected birds with the rank order of potency as follows: Drug combination >Diclazuril > Salinomycin. B- Body weight and weight gain: The body weight gain was significantly increased in the noninfected group treated with salinomycin after the end of the I”, 2Hd and 3~weeks post-drug treatment. except after 3 week post-treatment which revealed non significant changes. The same response was recorded with diclazuril after the end of the 1 SI week post treatment and the drug combination after the first day in the infected groups. D- Liver and Kidney function tests: Serum AST, ALT and Ap activities were significantly elevated in response to treatment with salinomycin in both non-infected and infected group after the end of the 21(1 week post drug administration. The same increase was observed after the end of the 3~ week in the infected non-treated group. The same effect was recorded for serum total proteins. Serum uric acid was significantly elevated after the end of the 2’~week post treatment with salinomycin into non—infected and infected groups. The same effect was noticed in infected non-treated group after the end of the 3d week. The same picture was recorded for serum creatinine except for salinomycin in the infected group where the increase appear also after the end of the 2ld week post-treatment. E— Serum electrolytes: Serum calcium and phosphorus were significantly decreased and increased in salinomycin treated groups (non-infected and infected), respectively after the end of the 2~ week in non-infected and infected treated group. The same effect was observed after the end of the 3tI week in the infected non-treated group.