الفهرس 
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Abstract
Amprolium is a heterocyclic compound that has been shown to possess a broad spectrum anticoccidial activity against most important species of coccidia. Halofuginone is antiprotozozal drug . It has a great potency against most of the Eimeria species at a level of 3 ppm of feed. Salinomycin is a monoglycoside polyether ionophore antibiotic produced by a strain of Streptomyces albus. It has been shown to be effective against coccidiosis. These drugs are routinely used, mixed with ration, in poultry farms from one day age through the 420_ day for controlling coccidia. Nevertheless, their abuse questioned the validity of their role in control of coccidiosis in poultry. Hence the present study was designed to address the most efficient use of these drugs by studying the effect of possible alternative replacements of their therapeutic doses.
I. Effect on the daily oocyst count : -
Our results reaveled that all experimental groups displayed
a complete disappearance of the oocysts on the 9th day of infection. However, the groups that received amprolium, halofuginone and salinomycin only for 10 days prior to infectionwith Eimeria tenella field strain disclosed normal decline on the daily oocyst count.
IL Effect on the body weight and body weight gain:-
By the end of the first week, all experimental groups revealed no significant effects on the body weight gain. By the end of the seconde week, the group treated with amprolium for 10 days prior to infection then salinomycin for 5 day postinfection displayed a significant increase in body weight and body weight gain compared with other treated groups or the control. The group treated with halofuginone for 10 days prior to infection followed by salinomycin for 5 day postinfection showed a significant increase in body weight and body weight gain compared with other treated groups or the control. The group treated with salinomycin for 10 days prior to infection followed by salinomycin for 5 day postinfection showed a significant increase in body weight and body weight gain compared with other treated groups or the control. Other treated groups were not significantly different from each other or the control. By the end of the third week, the same groups evoked a significant increase in body weight and body weight gain. Moreover, those given salinomycin for 10 days prior to infection then halofuginone 5 day postinfection displayed a significant increase in body weight and body weight gain. Other treated groups were not significantly different from each other or the control.
III. Effect on man weights : -
Administration of amprolium, halofuginone or salinomycin either
separately or in different replacements elicited no significant effects on organ weights.
IV Haematolozical effects : -
Administration of amprolium, for 10 days prior to infection and 5 day postinfection displayed a significant increase in leucocytic count. Substitution of amprolium, given 5 day postinfection, with halofuginone elicited a significant increase in erythrocytic count and haemoglobin percent. Replacement of amprolium, administered for 5 day postinfection, with salinomycin displayed a significant increase in both erythrocyic count and packed cell volume. Administration of halofuginone for 10 days prior to infection followed by amprolium for 5 day postinfection evoked a significant increase in leucocytic count and a significant decrease in haemoglobin percent. Replacement of amprolium, given for 5 day postinfection, with salinomycin induced a significant decrease in erythrocytic and leucocytic count and haemoglobin percent. Administration of salinomycin for 10 days prior to infection and 5 day postinfection displayed a significant decrease in both erythrocytic and leucocytic counts and a significant increase in haemoglobin percent. Salinomycin, given for 5 day postinfection, replaced by amprolium induced a significant increase in both leucocytic count and packed cell volume. Replacement of salinomycin administered for 5 day postinfection with halofuginone evoked a significant decrease in both erythrocytic and leucocytic counts. On the other hand, other treated groups displayed no significant difference compared with the control .
V. Effect on serum electrolytes : -
Our findings demonstrated that administration of amprolium for 10 days prior to infection followed by 5 day postinfection induced a significant increase in serum magnesium level. Amprolium given only for 10 days prior to infection displayed a significant decrease in serum calcium and magnesium levels. Administration of halofuginone for 10 days prior to infection then 5 day postinfection evoked a significant decrease in serum magnesium level. Halofuginone added only for 10 days prior to infection induced a significant decrease in both serum calcium and magnesium levels. Halofuginone given for 10 days prior to infection followed by salinomycin for 5 day postinfection displayed a significant increase in both serum calcium and phosphorus levels. Administration of salinomycin for 10 days prior to infection and 5 day postinfection elicited a significant increase in serum calcium level. Salinomycin added only for 10 days prior to infection displayed a significant decrease in serum calcium level and a significant increase in serum phosphorus level. Substitution of salinomycin, given for 5 day postinfection, with halofuginone disclosed a significant decrease in serum phosphorus level. Other treated groups were not significantly different from the control.