الفهرس 
CNS histology and histogenesis
CNS histogenesisOnly 14 pages are availabe for public view
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Abstract
The most recent classification of astrocytomas is the classification of the World Health Organization (WHO) for 2007. It gives important prognostic and therapeutic informations.
There are two types of astrocytomas. The more common group is of diffusely infiltrating astrocytomas. The less common one of is with a more circumscribed growth, preferentially develop in children and young adults, grow slowly, have a limited potential for malignant progression and can be cured by tumor resection.
Accurate identification of the abnormal is predicated on a thorough knowledge of the normal. Normal microscopic morphology of the CNS should be studied well with the specialized regional histology seen throughout the CNS.
Pseudoneoplasms of the nervous system vary greatly in nature and they all may mimic true tumors. Mass lesions such as demyelinating pseudotumors, abscesses, infarcts, and other rare lesions can mimic astrocytoma on neuroimaging scans and tissue sections. Thus, Knowledge of the pitfalls is essential to avoid mismanagement specifically overtreatment
The neuropathologist must be familiar with different brain tumours entities and the broad range of morphologic variations that each tumor may assume. Mistaking one tumor type for another, not recognizing common tumors arising in uncommon locations or not being familiar with rare tumor types or with recently described tumor types are all sources of the diagnostic error that may occur in interpreting brain tumours histopathology. Knowledge of the disease morphology, anatomical location, neuroimaging with the patient clinical information is critical before rendering a diagnosis.
The role of intraoperative pathological diagnosis is crucial in neurosurgery. Besides rapid decision making during neurosurgical procedures. Although conventional hematoxylin-eosin staining is the mainstay for pathologic diagnosis, IHC has played a major role in differential diagnosis and in improving diagnostic accuracy in neuropathology. Also recently new molecular markers have been developed. Some of these markers have shown diagnostic value.