الفهرس 
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Abstract
Psychotropic drugs are used in treatment of psychiatric disorders and some of them are used in Veterinary Medicine as preanaesthetics and tranquilizers. The use of such kind of drugs
has become widly spread only since the mid 195 Os. In the present work we chosed chiorpromazine hydrochloride representing phenothiazine derivetives , and diazepam representing benzodiazepine derivatives. Available literature failed to give full clinicobiochemical and histopathological picture about the effect of the two drugs on liver and kidney . Accordingly , the present work was done to clarify the whole picture and to correlate the clinicopathological results with that of the histopathological results Seventy albino rats were used in the experiment and
grouped into two main groups each of 35 animals , the first
group was again divided into three subgroups each of 10
animals and were treated with chlorpromazine at a dose of
10mg/kg. intraperitoneally for 21 42 and 63 days. The
remainder 5 animals were left as a control. The same was done with the second group which was treated with diazepam by gastric intubation at a dose of 3.5mg/kg. body weight The clinicobiochemical analysis showed a picture of cholestatic hepatocellular jaundice in all animals due to administration of either of the two drugs . This picture was manifested by directly proportional increase with time in ~ GTP, GOT , GPT , alkaline phosphatase , total bilirubin , direct and indirect bilirubin . Again the hepatocellular damage was mainfested by hypoglyca~emia , hypoalbuminaemia and hypercholesterolaemia The histopathological study of the liver confirmed the clinicopathological results . The liver showed congested blood
vesseles and sinusoides , proliferation of fibroblasts and
infiltration of portal triads with lymphocytes , macrophages and
eosinophils . Hepatic cells suffered vacuolar degeneration and
necrosis . Also there was bile ductular proliferation The blood chemistry study denoted the presence of chronic renal failure in all animals . This picture was mainfested by increase of B. U. N. and creatinine , but the increase in case of chlorpromazine was directly proportional with time of administeration and vice versa in case of diazepam. The flame photometry study on the serum electrolytes
showed no change in the sodium potassium and calcium.
Again the histopathological study confirmed our clinicopathological results The kidneys showed congestion of renal blood vessels and capillaries Renal epithelial cell lining suffered cloudy swelling , vacuolar and hydropic degeneration
renal parenchyma was infilterated with lymphocytes and
macrophages this occur in all animals on the two drugs
In conclusion these drugs have a great harmful effect
on liver and kidneys when applied for 21 42 and 63 days
therefore it should be used very cautiously and not for long
periods