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Abstract infections, Regarding the outcome attributable to nosocomial infections, Fagon et al 1993, Pittet et al 1994 demonstrated excess mortality, prolonged ICU stay, higher antibiotic consumption, and increased therapeutic activity, which led to considerable cost overruns,we found that mortality attributable to nosocomial infection exceeded 40%, a value that corresponds to a relative risk of death equal to 4 Moreover, mortality was significantly greater among case-patients acquiring more than one nosocomial infection than in paired controls. The same results have been reported by (girou et al 1998) Alternatively, aspiration may play a role. Although aspiration was not more frequent among obese patients on ICU admission in this study, obese patients, who have greater incidence of difficult intubations and complications from intubations may be more likely to have aspirated after ICU admission which may further influence their risk for developing ARDS. In addition, obesity has been found to promote the inflammatory response and endothelial changes commonly seen in ARDS. (Frat et al 2008) This study aimed to evaluate the impact of C - reactive protein and body mass index on patient outcome admitted in respiratory intensive care unit (RICU) in Abbassia chest hospital during the period from January2011 to July2011. This study included 71 patients first admitted at ICU, aged above 20 years; all patients were subjected to full history taking, clinical examination was done included weight and height measurement for calculation of BMI, routine laboratory tests included C – reactive protein assay using semi quantitative method. The results show insignificant correlation between smoking , need of mechanical ventilation, duration of MV, length of stay in ICU,outcome as regard CRP level. There was high significant correlation between BMI categories and outcome in which mortality rate was high among under weight,also significant correlation as regard complications in which septicemia were more common in underweight, Complications of mechanical ventilation was more common in morbid obese, nosocomial infection was more common in obese. |