الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
 |  | from | 83 |  |  |
| | | from | 83 | | |
Abstract
Sepsis is the commonest cause of neonatal mortality and is responsible for 30-50% of total neonatal deaths each year in developing countries. It is estimated that up to 20% of neonates develop sepsis and approximately 1% die of sepsis related causes (Tripathi et al., 2010).
Neonatal sepsis, sepsis neonatorum and neonatal septicemia are terms that used to describe the systemic response to infection in newborn infants (Lott, 2003).
Although the term “sepsis” has been around since ancient times, modern definitions of “sepsis” were described in detail in the early 1990s, at a consensus conference convened by the American College of Chest Physicians and the Society of Critical Care Medicine. At that time, “sepsis” was described as a systemic response to a physiologic insult – including infectious and other etiologies – that lead to the development of further organ injury, ultimately culminating in multiple organ dysfunction syndrome(the American College of Chest Physicians and the Society of Critical Care Medicine 1992). Neonatal sepsis, also termed Sepsis neonatorum, refers to a group of physical and laboratory findings that occur in response to invasive infection within the first 30 days of life. The infection may involve the infant globally or may be limited to just one organ (such as the lungs with pneumonia). It may be acquired prior to birth (intrauterine sepsis) or after birth (extrauterine sepsis).