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Abstract Experimental trial for vaccination was conducted, where, two groups of susceptible calves (GI and Gil) were vaccinated against B. bovis using two types of killed vaccines (erythrocytic and merozoite vaccine respectively). A third group (Gill) was kept as non vaccinated controls. Vaccinated animals responded normally to vaccination. The level of serum antibodies against B. bovis was in the first group (erythrocytic vaccine group GI) higher than that of the second group (merozoite vaccine group Gil). No clinical adverse reactions could be observed in vaccinated animals and the body temperatures were in their normal ranges as in control non infected group. The two tested vaccine types proved their safety as no detection of parasitaemia in blood of vaccinated animajs throughout an observation period of 42 days post vaccination. The vaccinated animals in the first group (GI) could withstand challenge with the virulent strain of B. bovis more efficiently than those of the second group (Gil). The third group (control group Gill) developed the picture of infection with babesiosis afier infection with the virulent strain. It could be concluded that the erythrocytic vaccine in regarding to immunity and easier method of preparation could be applied for vaccination of cattle against B. bovis. |