الفهرس 
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Abstract
Rabbits represent a good source of animal protein of high
nutritional value in Egypt Bacterial or fungal infections represent a very common medical problem affecting rabbit breeding in Kalyobia govemorate This study aimed to isolation of the common pathogenic bacterial and fungal species and throwing light on simple and recent dia~ostic and therapeutic regimens . A total number of 360 ( 120 apparently healthy and 240 diseased or recently dead ) were collected from 5 different rabbit farms at Kalyobia governorate. The used rabbits were of different groups different sex and breeds. Samples were taken from the lungs , liver spleen and intestine of each rabbit under aseptic conditions and subjected to fungal and bacteriological studies E. cob represents the most common isolates from the healthy group ( 174 out of 334 isolates ) Other bacterial species were recovered from the healthy group including Streptococcus faecalis ( 52 isolates ) , Pneumococci ( 24 isolates ) Pseudomonas aeruginosa ( 30 isolates ) and Klebsiella ( 5 isolates).
A total of 214 fungal isolates were recovered from the
healthy group , including Aspergillus fumigatus ( 80 isolates),
Mucor (64 isolates ) and Penicil]irn ( 70 isolates )
Isolates from the diseased and recently dead rabbits revealed
species E. coil represents the most common 10 bacterial isolates ( 780 isolates ) Other bacterial isolates include Pasteurella multocida ( 286 isolates ) Pseudomonas aeruginosa ( 1 08 isolates ) , Staphylococcus aureus (1 8 isolates ), Streptococcus faecalis ( 72 iso] ates ) , Pneumococcj ( 73 isolates ) Corynebacterium pyogenes (48 isolates), Kiebsiella pneumoniae ( 46 isolates ) , Citrobacter freundil (28 isolates) and Hafnia alvei ( 20 isolates ) . Funga.l isolates from the examined organs of the diseased and recently dead rabbits revealed 7 fungal species including Aspergillus niger ( 186 isolates ) , Aspergillus flavus ( 190 isolates ) , Aspergillus fumigatus ( 132 isolates ) , Aspergillus terrus (24 isolates ) Aspergillus candidus ( 16 isolates ) , Penicilliurri (208 isolates ) and Mucor (110 isolates).
Serological identification of the isolated E. coil revealed the
serotypes 028 , 0115 , 025 and 0124 in order of prevalence,
while serotyping of Pseudomonas aeruginosa isolates revealed only two strains polyvalent I group A and polyvalent III group N.
The susceptibility of the important bacterial species to
different antibiotics were tested . All K. coil strains show high
sensitivity to tarivid , piflacine , nalidixic acid and noraxin
Pasteurella multocida is highly sensitive to tarivid , noroxin, garamycine rimactane and suiphonamides and lincomycin
Pseudomonas aeruginosa is highly sensitive to noroxin
gararnycin , piflacine and erythromycin Corynebacterluin
pyogenes is highy sensitive to amikacin , noroxin , sulphonarnides and garamycin.
The pathogenicity of the important bacterial and fungal
isolates including E. coil , Pasteurella multocida , Pseudomonas aeruginosa , Corynebacterium pvogenes and Aspergillus fumigatus were tested in 6 — 8 weeks old New Zealand white rabbits by different routes of infection It is found that the JIM route is much more effective than the oral route in most bacterial isolates . The most rapidly fatal E. coil strain is the serotype 028. Pseudomonas aeruginosa was proved or highly pathogenic with fatality rat reaching 100 % in both SIC and JIM infection Aspergillus inoculation is highly fatal with I/V route and to less extent by J/M and oral routes Mixed infection with strain and other bacterial as well as fungal isolated in fatality rate reaching 100 % with the all used organisms.
The effectiveness of gararnycin and noroxin as therapeutic
and prophylactic drugs in various rabbit infections were tested on a group of healthy rabbits . It is found that garamycin is effective in both prevention and treatment of diseases caused by Pasteurella, Corynebacterium and Pseudomonas , but ineffective in treatment of E. coil infection Noroxin was found to be highly effective during both prevention and treatment of all isolated bacterial species . Mycostatin is effective prophylactic and therapeutic measure in Aspergillus infection.