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Abstract This study was carried out in the Research Unit of Fish Physiology, Faculty of Veterinary Medicine, Menofia University (Sadat Branch). In the period between July 2010 and November 2010. The aim of the study was to evaluate the effect of partial replacement of soybean meal with autoclaved and acid treated with acetic acid 17% on growth parameters, anemia screening parameters, immunity profiles, protein profiles, lipid profiles, chemical analysis of fish body, dry matter digestibility%, and dressing %. This study was carried out on 1000 African catfish fingerlings (10.0g) was distributed into three tanks (1.0m3) for three weeks to acclimate fish with the new environmental conditions. After acclimation 875 / African catfish fingerlings were used and distributed into five groups (175 / fingerlings / group / tank) for 12 weeks and they were divided as follow: * Group 1: the control group and was fed with the control diet containing 100% soybean meal. * Group 2: was fed on the diet in which the soybean meal was replaced with 25% autoclaved shrimp by-product meal. * Group 3: was fed on the diet in which the soybean meal was replaced with 25% acid treated shrimp by-product meal. * Group 4: was fed on the diet in which the soybean meal was replaced with 50% autoclaved shrimp by-product meal. * Group 5: was fed on the diet in which the soybean meal was replaced with 50% acid treated shrimp by-product meal. The sampling was carried out as follow: 1- Weighting: at day zero then every 2 weeks (10 fingerlings / group). 2- Blood sampling: at day zero then every 4 weeks (10 fingerlings / group). 3- Fish body sample: at day zero at the end of study period (3 fingerlings / group). 4- Fecal samples: every 4 weeks till the end of this study. 5- Dressing %: at the end of the study 5 fish were weighted and slaughtered and reweighted after removal of head and viscera. The results and statistical analysis indicated that: 1- Growth parameters: a- Mean body weight: the study revealed a significant difference in G4 and G5 relative to other groups at P<0.05. b- Mean weight gain: the study found a significant difference in values of G4, and G5 (101.38±1.14, 103.68±0.84) respectively relative to values of G1, G2, and G3 (94.22±1.37, 97.00±0.09, and 97.66±1.22) respectively, at P<0.05. c- Mean weight gain %: the study revealed a significant difference in value of G2, G3, G4, and G5 (518.16±4.30, 499.10±4.18, 473.53±4.94, and 479.60±4.90) respectively, relative to the value of G1 (458.03±3.34) at P<0.05. d- Average daily gain: the study confirmed a significant difference in the values of G4, and G5 (1.21±0.030, 1.23±0.036) respectively relative to values of G1, G2, and G3 (1.12±0.023, 1.16±0.030, and 1.16±0.033) respectively, at P<0.05. e- Feed conversion ratio: the study concluded a significant difference in the value of G1 (1.21±0.039) relative to values of G2, G3, G4 and G5 (1.17±0.04, 1.16±0.041, 1.14±0.046 and 1.11±0.044) respectively, at P<0.05. f- Protein efficiency ratio: the study found a significant difference in the value of G3 and G5 (2.86±0.11, 2.71±0.11) relative to values of G1, G2, and G4 (2.56±0.08, 2.64±0.09, and 2.78±0.11) respectively, at P<0.05. |