الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
In this Study Fifteen female Balady Egyptian goats were used within
age of 9 to month and body weight between I 8 10 2 I Kg. And they
were divided into two groups
Group -A consistes of 5 animals and used as control group
Group -B consistes of 10 animals and used as experimental animals for
inducing of hypomagnesaemja by oral administration of potassium
chloride and citric acid until the charactrestic symptoms of
hypomagnesaemja were appeared Then this group was divided into
two subgroups in the treatment as the following Whole blood samples were collected on the anticoagulant at
5,10,15,20 and 24th• day of the experiment and 4 and 12 hours after
treatment of both groups for determination of RBCs and WBCs count
,PCV., FIb, and blood indices Also serum samples were collected every 48 hours until the charactrestic symptoms of hypomagnesaernia were appeared and after 4,12 and 24 hours after treatment of both groups for determination of the level of magnesium , calcium, phosphorus, potassium, sodium, total protein, blood glucose, urea , creatinine , GOT, GPT, CPK,LDH, and ALP. Also PTI-I was measured in the I 8 and 24 clays of the experiment and 24 hours after treatment in both group. Urine , ruminal juice , saliva and erythrocytic samples were collected every 48 hours until the symptoms were appeared and also were collected after treatment by 4,12 and 24 hours in both groups for measuring concentration of magnesium in such body fluids . Also samples of CSF. were collected at 6,12, 18 and 24~’. day in the diseased animals and after 24 hours after treatment of both groups for measuring of the concentration of magnesium Electrocardiograph used in diagnosis of hypomagnesaemic animals and also used after 12 and 24 hours after treatment for measuring the changes in the ECG parameters before and after treatment. The obtained results of this study revealed that The symptonis of hypomagflesaemia were began to appeared at the I~ day of the experiment and were very promenante at the 24111. day , in the form of signiflcant increase in the respiratory , pulse rat and body temperature , hyperasthesia colnic convulsions , tremors , loamy salivation , and spasmodic urination and defecation The biochemical changes of diseased animals revealed that, there
were significant decrease in the serum level of magnesium, calcium,
phosphorus, PTH, and glucose, while there were significant increase in
the activities of serum GOT, CPK , LDH, ALP, potassium and creatinine
while there were no significant changes in the serum level of sodium
GPT, total protein Concentration of magnesium in the urine , CSF and erythrocytes were significantly decreased in the diseased animals , while magnesium concentration in the saliva and ruminal juice were not significantly changes in the diseased animals
Electrocardiographic finding of the diseased animals revealed that
there were significant increase in the amplitude of T- wave and QRS
complex , while there were significant decrease in the duration of QT and ST intervals ,while there were no significant changes in the P- wave and PR intervals
I-I istopathological studies revealed presence of calcification in the
kidneys, hyalin degeneration of the skeletal muscles and leukocytic
infilteration in the muscles and kidneys with slight degree of degeneration in the liver A fter treatment the ci inical sym ptoms were completely disappeared without relapse after both treatment ( LI and T—2). Also the biochemical. control group , Also the electrocardiographic changes were returned to
the normal conditions after both treatment (T- 1 and T-2) within 24 hours In comparison between the results that obtained after using ofT— I and that alTer using of ‘1—2 we found that , there were lhster signilicant improvement in [lie serum level of magnesium , calcium CPK and creatinine after T-2 than that after T-l. Also concentration of magnesium in the urine , CSF , rurninal juice and erythrocytes were rapidly increased after T -2 than T- I from this study we can recommend :- — Measurement of magnesium concentration in other body fluid such as urine it , CSF, and erythrocytes rather than serum can help in early diagnosis of hypomagnesaemia
— Administration of magnesium chloride orally beside intravenous
and subcutaneous administration of magnesium sulfate may help in
the rapid improvement of hypomagnesaemia
— Administration of vitamin —D3 with the treatment program of
Hypomagnesaemia.