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Abstract In this work two nutritional deficiency problem and another metabolic disorders were studied as following. Group I: About 30% of the animals in a flock of balady sheep about 3- 6 years- old were found suffering from alopecia and achromatrichia. Blood samples were collected from twenty affected animals before and after treatment. Clinical and laboratory studies were conducted to evaluate the causative factors. The observed clinical sings were alopecia, easily detached wool, achromatrichia, diarrhea, lameness, unthriftiness and pale mucous membrane. The laboratory findings included the following: - The mean values of serum copper, iron, manganese and zinc are significant decreased in alopecic animals before treatment than after treatment. - The mean values of serum calcium and inorganic phosphorus showed no significant difference in alopecic animals before and after treatment (Table, 2). - The mean values of serum total proteins and total lipids were also significantly dropped before treatment than after treatment, while those for urea, alkaline phosphatase, alanine aminotransferase and aspartate amino transferase were significantly increased before treatment than after treatment (Table, 3). - The concentration of serum albumin in affected animals showed decreased values, while those for globulins were increased before treatment than after treatment (Table, 4). - The concentration of copper, manganese and zinc in samples of wool in alopecic sheep showed significant decreased values before treatment than after treatment (Table, 5). Group 11: Thirteen balady pregnant ewes (3- 5 years- old) were chosen from a private flock of sheep showing clinical signs of pregnancy toxaemia. Diseased ewes exhibited one or more of the clinical signs: anorexia, depression, disinclination to move, drowsiness, excess salivation, grinding of teeth, blindness, sternal recumbency and abortion. Blood samples were collected and used for laboratory analysis and revealed the following: - Significant dropped values of serum glucose, cholesterol, triglycerides and phospholipids and significant increased values of free fatty acids. These values returned to normal after treatment (Table, 6). - The concentrations of serum urea and creatinine showed an elevated values in diseased ewes before treatment than after treatment (Table, 7). - The activities of serum alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase were elevated before treatment than after treatment. - The concentration of serum calcium showed non significant difference before and after treatment, while inorganic phosphorus and magnesium were significantly dropped before treatment than after treatment. - The concentrations of serum albumin were significantly decreased, while those for afla- 1- globulin and beta-i- globulin and consequently total globulins were significantly increased before treatment than after treatment (Table, 7). |