الفهرس 
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Abstract
Ovarian cancer is the leading cause of death among all gynecological malignancies in developed countries.
Eighty to ninety percent of ovarian cancers are epithelial, and more than two thirds are diagnosed at an advanced stage.
Treatment of patients with ovarian cancer requires multimodal approach. Surgery and chemotherapy are the most contributing factors to the management of ovarian cancer.
The current standard of management for a patient with advanced (Stage III or IV) ovarian cancer is cytoreductive surgery followed by administration of systemic chemotherapy.
The aim of the study is to determine the impact of neo-adjuvant chemotherapy on surgical debulking rate (partial & total), intra-operative morbidity, post-operative morbidity and quality of life in patients with advanced stage (stage III) epithelial ovarian carcinoma.
The study was conducted on 30 women selected from patients attending the gynecologic clinic of El Shatby Maternity University Hospital. All cases were selected after fulfilling criteria of inclusion into the study. Cases were randomly divided into two groups. Group I included 15 women who were undergone upfront surgery then adjuvant chemotherapy. Group II included 15 women, subjected to neo-adjuvant chemotherapy then interval debulking surgery.
Patients were admitted to hospital and then, written informed consent was taken. Full history was obtained including; age, menstrual status, gravidity, patient’s complaints, duration of illness and family history. Complete laboratory investigations included; Complete blood picture, renal functions, liver functions, tumor markers (CA125, CEA) and cytological examination for ascetic fluid. Radiological examination included; plain chest x-ray, ultrasound of abdomen & pelvis, CT of abdomen & pelvis.
We found that most of patients that undergone interval debulking surgery had optimum debulking of all tumor tissue. As regard duration of surgery we found that 93.3% of patients in IDS had their surgery with a duration less than two hours but in upfront surgery only 20%. As regard intra-operative morbidity we found that only 20% of patients in IDS lost more than one liter intra-operative but in upfront surgery 73.3% of patients lost more than one liter.