الفهرس 
CHRONIC LIVER DISEASEOnly 14 pages are availabe for public view
 |  | from | 114 |  |  |
| | | from | 114 | | |
Abstract
Children with chronic liver disease are at risk for developing vitamin K deficiency because of fat malabsorption and inadequate dietary intake.
This study was conducted on 50 infants, children and adolescents, suffering from chronic liver disease (30males and 20 females). They age ranging from 1.5 to 16 years.Our patients were divided according to the type of liver disease into 2 groups: group 1 (cholestatic) & group 2 (non cholestatic).
All were subjected to thorough medical history taking with special emphasis on hepatic symptoms and bleeding tendency symptoms, full clinical examination, investigations for liver functions, and measurement of serum PIVKA II levels before and after vitamin k administration. Assessment of liver diseases severity was done and patients were categorized according to The Child-Pugh classification to Child A, B, C.
Then collected data were reviewed, coded, and entered PC where statistical analysis was done using SPSS (statistical package for social science) which revealed that:
- PIVKA II levels were elevated in all patients with chronic liver disease (cholestatic and non cholestatic) but higher among children with cholestatic chronic liver disease.
- All patients (100%) with bleeding tendency symptoms showed elevation in PIVKA II level while only (64.7%) of them showed elevation in the INR.
- After vitamin K administration PIVKA II levels showed evident reduction in both groups being more significant in the non cholestatic group, but PIVKA II never reached the normal level.
- There was a significant positive correlation between PIVKA II and Child’s classification and incidence of bleeding.
- There was a significant positive correlation between PIVKA II and PT, INR, TSB, DB and GGT.
- There was a significant negative correlation between PIVKA II and albumin and hemoglobin.