الفهرس 
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Abstract
Carbamazepine and sodium valproate are anticonvulsant drugs used for management of epilepsy. This study was done to evaluate and
compare the short-term chronic toxicity of these two drugs in adult
albino rats by studying their effects on the liver and kidney
histopathologically and biochemically, as well as their effects on the
. chromosomal pattern.
This study was conducted on 180 adult albino rats weighing
approx imately 130-150gm each. They were classified into three groups,
. first group was used as a control, second group was used for
.carbamazepine and the third group’” was used for sodium valproate. This
.study was done throughout three periods (two weeks, four weeks and
after stopping of drugs) to evaluate short-term chronic
The hepatic biochemical changes of both drugs revealed very
increase in bilirubin, AST, AL T, and ALP (P< :’.0005) compared to the control. These results were confirmed by the
?&tstopathological changes which were mild cellular infiltration with
lymphocytes, fatty changes, dilatation and congestion ”Of central vein after 2 w.s administration of carbamazepine. These
~~ions increased after 4 +ks with bile duct narrowing, dilat~tion and
.wngestion of portal vein