الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 187 |  |  |
| | | from | 187 | | |
Abstract
Cholesteatoma refers to the presence of a stratified
keratinizing squamous epithelium that expands within the
middle ear cleft, proliferation and differentiation of keratinizing
epidermal cells appears to be an important factor in the
pathogenesis of middle ear cholesteatoma. The factors involved ”
in the process of epithelial migration, differentiation and
proliferation are complex and numerous, they are not fully
understood.
• The aim of this work was’ to detect the hyperproliferative
activity in cholesteatoma by using MIB-I a hyperproliferative
marker and comparing this with the hyperproliferative activity
of post-auricular normal skin.
• The study conducted on 30 patients suffering from aural
cholesteatoma and 5 samples of post-auricular skin was taken
as a control group.
• The cholesteatoma· samples and the control group were
subjected to immuno-histochemical staining by using the
hyperproliferative marker’MIB-I.
• The study showed that, the proliferative score of middle ear
cholesteatoma is higher when compared with the post-auricular
normal skin, the differellce was statistically significant.