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Abstract Quality of life represents a broad range of human experiences related to one’s overall well- being and may be influenced by a multitude of nonmedical factors, such as financial status, individual freedom and one’s own personal environment. The assessment of quality of life in clinical trials, however , is concerned with the more defined concept of healthrelated quality of life (HRQOL) which has been described as” the functional effect of an illness and its consequent therapy upon a patient as perceived by the patient” t f I These definitions emphasize that ”individuals” overall evaluations of their satisfaction or happiness in major domains of life. Historically these evaluations were known as ”life satisfaction” or ”subjective wellbeing” and are now referred to as ”global QOL” or ”overall QOL”. Psychiatric morbidity is defined as the presence of handicapping abnormalities of emotions, behavior, and relationships that impede personal and social functioning Chronic illnesses 111 children and adolescents have devastating influence on them and their families. The patients have to cope up with illness medication and its influence on their development. Consequently a large number of them have emotional disorders which influence the course and outcome of physical disorder There are general risk factors in the chronic diseases for psychiatric morbidity and low quality of life scores: -Incidence of disease ~plication, |