الفهرس 
AcknowledgmentOnly 14 pages are availabe for public view
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Abstract
PV is an uncommon chronic mucocutaneous autoimmune disease. It is characterized by the presence of autoantibodies directed against epithelial intercellular adhesion molecules. The aim of the present study was to evaluate the possible alterations in the levels of Cdk2 expression in both oral mucosal and skin tissue of PV patients in comparison to BP patients and controls. 27 individuals were recruited from the out-patient clinic of Dermatology Department, Faculty of Medicine Cairo University and Oral Medicine and Periodontology Department, Faculty of Oral and Dental Medicine Cairo University. Twelve patients were suffering from PV and classified into severely involved patients Group I (B) and moderately involved patients Group I (A) groups, and (10) patients suffering from BP (Group II). In addition to (5) healthy normal individuals served as controls (Group III). Punch biopsies of oral and skin tissue were taken from PV patients. However, only skin biopsies were taken from BP patients. Sections were cut for histopathological examination and for Cdk2 immunostaining. The obtained results were collected, Cdk2 immunostaining expression in Group I (PV patients) was higher than Group II (BP) and controls. It was concluded that Cdk2 might play an important role in the pathogenesis of PV. This is may be due to acantholysis process enhancement and immune\inflammatory response development