الفهرس 
Acne VulgarisOnly 14 pages are availabe for public view
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Abstract
Acne is a chronic disease of the pilosebaceous follicle that causes polymorph cutaneous lesions, among them comedones, papules, cysts, pustules, and abscesses which, after regression, may leave scars.Acne is considered the most common dermatologic illness, with greatest prevalence in adolescents. It affects 80% of adolescents, but also may be observed in 54% of adult women and 40% of adult men. It is characterized by periods of exacerbation alternated with periods of stability. The face, anterior trunk, and upper back are the most commonly affected areas due to a greater concentration of SGs in these areas.The pathogenesis of acne is multi-factorial, including 4 primary pathogenic factors, which interact in complex manner to produce acne lesions as alteration in the keratinization process, P acnes follicular colonization; Sebum production by the sebaceous gland; inflammation and immunological factors Toll like receptpor-2 is a major class of PRRs that is involved in detecting invading pathogens in the skin and initiating cutaneous immune response. Eleven TLRs are identified in humans, all of which share similarities in their structure and function, but respond to different microbial components or endogenous ligands. There are differences among the TLR signalling pathways which leads to the different immune responses against given stimuli.