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Abstract olycystic ovarian syndrome is a common endocrine disorder in women of reproductive age group. In the part, the diagnosis of polycystic ovary syndrome was bared on National Institute of Health (NIH) criteria. In 2003 at a joint meeting of the European Society for Human Reproduction (ESHRE) and the American Society of Reproductive Medicine (ASRM), new guidelines for the diagnosis of PCOS were suggested. The Rotterdam consensus group revised the diagnostic criteria of polycystic ovarian syndrome: any two of the following criteria are essential for diagnosis of PCOS: - Oligo and/or anovulation. - Clinical and/or biochemical signs of hyperandrogenism and with exclusion of other cases of hyperandrogenism (congenital adrenal hyperplasia, androgen secreting tumors and Cushing‘s syndrome). - Polycystic ovaries by trans-vaginal ultrasound Ovarian reserve is related to size, number and quality of oocyte within follicles. The ovarian reserve is the reproductive ability of ovary that shows number of follicles in it. Aging decrease ovarian reserve and subsequently reproductive ability of women. Evaluation of antimullerian hormone (AMH) serum level can be use as predictor to ovarian reserve. Serum AMH levels disappeared in cycle bleeding and whole cycle has minimum intracycles changes. The aim of this study was to evaluate the effect of laparoscopic ovarian drilling on ovarian reserve in patients with polycystic ovarian syndrome before and after LOD measured by serum anti-mullerian hormone levels ,FSH ,ovarian volume and AFC . This study was conducted at Ain-Shams Maternity University Hospital including 38 patients of polycystic ovarian syndrome candidate for laparoscopic ovarian drilling (clomiphene citrate resistant patients). Polycystic ovarian syndrome was diagnosed according to the Rotterdam criteria. Patients with age 19-35 years, presence of ovarian pathology detected by transvaginal ultrasound were excluded from the study |