الفهرس 
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Abstract
Dietary restriction is considered as a critical subject to study due to its role in improvement of overall health and decreasing the deleterious effect of aging in animals. This study was carried out to investigate the effect of caloric restriction on antioxidant status, lipid peroxidation and lipid profile in serum of young and adult age rats. The experiment was extended for two months and animals were sacrificed at the end of first and second month. This study was carried out on forty rats of which twenty young rats and twenty adult rats. These animals were subdivided into eight groups; each of five rats as following: Young Control 1st Month (YC 1),Young Control 2nd Month (YC 2) ,Young Restricted 1st Month (YR1) Young Restricted 2nd Month (YR 2), Adult Control 1st Month (AC 1), Adult Control 2nd Month (AC 2) Adult Restricted 1st Month (AR 1) and Adult Restricted 2nd Month (AR 2) This study revealed that caloric restriction in young and adult age increased in the activities of SOD, CAT and GPx in comparison with other groups of rats that fed on control diet In the same manner, GPx immunolocalization was showing a strong to moderate signals in young and adult groups subjected to caloric restriction. Moreover, caloric restriction showed a significant decrease in age associated lipid peroxidation in rats. Caloric restriction revealed a significant decline in total cholesterol, triacylglycerol, LDL-c and total lipid. In the same manner, caloric restriction would result in a significant increase in HDL-c.