الفهرس 
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Abstract
Acne vulgaris is a common disease one that has increased in frequency in the last half century, particularly among adult women. While the experience of acne may not be life threatening per se, it does carry with it significant psychological disability. Indeed the psychological sequelae of acne include higher rates of clinical depression – up to three times higher than the general population. For most patients acne remains a nuisance with occasional flares of unsightly comedones, papules , pustules, and nodules. For other less fortunate persons, the severe inflammatory response to Propionibacterium acnes results in permanent disfiguring scars.
Four ultimate factors are responsible for acne:
1) increased sebum production
2) hypercornification of pilosebaceous duct
3) abnormal bacterial function
4) production of inflammation.
The sebaceous gland is a holocrine gland, and its secretion is formed by the complete disintegration of the glandular cells. Excreting sebum is the major function of sebaceous glands, and increased sebum excretion is a major concurrent event that parallels the development of acne lesions. The pilosebaceous unit is an immunocompetent organ. Keratinocytes and sebocytes may act as immune cells capable of pathogen recognition and abnormal lipid presentation. Seborrhoea is, indeed, not a sufficient condition for the development of the pathology,Several variations in lipid metabolism have been described in acne patients, including a decreased amount of linoleic acid ,desaturation of sebaceous fatty acids may contribute to acne development.
The NO is a free radical that is generated in cells from L-arginine by the NO synthase enzymes. It is generated during immune and inflammatory responses and is implicated as a pro-inflammatory agent.
There is a increasing evidence that NO may be involved in the pathogenesis of various diseases including acne vulgaris . Serum nitrite/nitrate level, which is an index of NO production, was well reported to correlate with disease activity in various diseases . Therefore, we hypothesized that increased serum level of NO thus presents another important potential mechanism in the pathogenesis of acne vulgaris and it may be correlated with disease activity.
An association between diet and acne has long been postulated, but studies that have examined the impact of diet on acne have produced controversial results. Some have indicated that diets high in carbohydrates and fat worsen acne, while others did not detect this relationship .
Study was a trial to detect the role of oxidative stress and percentage of body fat in acne vulgaris.