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Abstract The present experiment was conducted to investigate the effects of copper deficiency in goats on, DNA, chromosomes, serum antioxidant enzymes, bone density and histopathological examination. A total number of 16 male goats of 12 months to 1.5 years old were used in the present experiment for 24 weeks. The male goats were randomly divided into two groups. The first group consisted of six animals and was kept as control fed copper sufficient diet. The second group was consisted of ten male goats fed diet treated with molybdenum and sulphur for 24 weeks. Blood samples were collected from all experimental animals every 6 weeks for 24 weeks with heparin for estimation of SOD, chromosomal analysis and comet assay; and without anticoagulant for estimation of Cu and Cp levels in serum. The clinical signs were rec orded throughout the experimental period. At the end of experiment 3 animals from both experimental groups were exposed for bone x-ray for detection of any skeletal abnormalities. Then were slaughtered for measurement of bone density using C.T. and for detection of histopathological changes induced by Cu deficiency. Clinical examination of hypocupremic goats showed changes in hair color and texture at the 9th week of the. The copper deficient animals were depressed, listless, nervous (hyperesthesia), anemic (exhibited pale mucus membranes) and diahorric in some goats, as opposed to control group. |