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العنوان
Gastrointestinal Stromal Tumors Clinico-Pathological Study /
المؤلف
Manie, Tamer Moustafa.
هيئة الاعداد
باحث / تامر مصطفى منيع
مشرف / محمد محمود
مشرف / ا.د هدير احمد المحلاوى
مشرف / طارق احمد
الموضوع
Gastrointestinal Stromal Tumors.
تاريخ النشر
2008.
عدد الصفحات
132 P. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
علم الأورام
تاريخ الإجازة
1/1/2008
مكان الإجازة
جامعة القاهرة - معهد الأورام القومى - طب الاورام
الفهرس
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Abstract

Purpose The Purpose Of Our To Study And Assess The Clinicopathologic Criteria Of Gists Which Affect Prognosis After Surgical Treatment. Patient And Methods A Retrospective Study For 33 Cases Done In NCI & MOC Between Jan. 2001- December 2006 And A Prospective Study For 34 Cases Done Also In National Cancer Institute And Minai Oncology Center Between Jan 2007 - Jan 2011 . All Patients Were Evaluated Pre-Operatively And Underwent Exploratory Laparotomy With Curative Intent; They Were Followed Up For Periods Ranging Between 24 – 60 Months. Results Among The 67 Patients, There Were 25 Males & 42 Females And 77.61% Of Patients Were Above 40 Years. Clinical Findings Were; Abdominal Pain (40.3 %), Abdominal Mass (38.8 %) And GIT Bleeding (34.8 %). The Stomach Was The Most Common Site Of Origin Of The Disease (49,3 %) Followed By Small Intestine( 28.4 %). Tumors Were High Grade In( 70.1 %) & Low Grads In (29.9 %) Complete Resection Of All Gross Disease Was Accomplished In 53 Patients (79.1 %) And Residual Disease In 14 Patients (20.9%) . Overall Survival & Disease Free Survival Were Statistically Significant. And Were Effected By Size Of The Tumor (More Than 5cm) ,High Grade Tumor , Resection Status . II Conclusion Surgical Resection, Including En Block Resection Of Locally Advanced Tumors, Remains The Only Curative Treatment. Overall Survival And Disease Free Survival Were Significantly Affected By Size Of The Tumor, Grade Of The Tumor And The Resection Status. Key Wards Gastrointestinal Stromal Tumor- GIST – Sarcoma – CDII7 –CD34 – Therapy – Surgery.