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Abstract Uterine sarcomas include a heterogeneous group of rare tumours that usually have an aggressive clinical behavior and poor prognosis. Clinical staging, histologic cell types, grades, mitotic index and DNA ploidy are important prognostic factors predicting the overall and disease free survival. This retrospective study highlights the experience of management and surgical approaches offered to uterine sarcoma in National Cancer Institute, Cairo University during the period January 2000- December 2007. The study included fifty seven patients with pathologically proven uterine sarcoma and subjected to different types of management at our institute. In our study FIGO staging is the most significant prognostic factor affecting both overall and disease free survival. In our study, external beam radiotherapy with or without brachytherapy seemed to improved local disease control with better results in early stage. Despite using adjuvant treatment survival rates were very poor with 2- year survival 37.6% and 4-year survival 22.2% Key words: uterine sarcoma, surgical approaches, FIGO staging, external beam radiotherapy, brachytherapy, overall survival, disease free survival. |