الفهرس 
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Abstract
Some herbal plants play a nutraceutical role to improve health, ameliorate the oxidative stress and eliminate risks which brave quality of life of both healthy individuals and patients by decreasing the complications of their suffering diseases. Oleo-gum resins of Boswellia carteri
are used as traditional medicine for reducing risks of a variety of lethal diseases as antiinflammatory
and anti-carcinogenic activities. In view of such activities of the oleo-gum resins and its components, the bioactive chemical compounds in the Boswellia carteri oleo-gum resins water extract were investigated and the effects of oral doses on colon cancer were tested through different biological and biochemical measurements.A number of adult male albino rats were divided into 5 groups; 3groups were given oral doses of Boswellia carteri water extract pre and/or post treatment of colon cancer induction with DNCB, in addition of 2 groups of healthy and malignant rats.
The chemical analysis of Boswellia carteri water extract revealed that each 100 ml of
the prepared Boswellia carteri gum resins water extract contains 180 ± 3.0 mg as GAE for total phenols, 0.58 ± 0.01mg as catechin equivalent for flavonoids, 7.6 ± 0.2 μg of anthocyanins, 10 ± 0.7 mg as tannins, 1.05± 0.02 mg as saponins, 0.92 ± 0.02 mg as alkaloids. The tested water
extract also showed high free radical scavenging activity; 1,1-diphenyl-2-picryl hydrazyl
(DPPH) radicals was scavenged by about 94.1± 1.8%. The biological trial showed that oral
consumption of Boswellia carteri gum resins water extract before and after colon cancer induction (pre/post) caused significant enhancement in the nutritional parameters; animals food intake, feed efficiency ratio as well as the body weight (P<0.05) as compared with malignant
group. The water extract given as pre/post oral doses for malignant rats caused significant increment in the blood levels of hemoglobin, hematocrit, RBC’s count, serum iron and lymphocyte percentage by 67.4%, 37.3%, 42.0%, 25.5% and 107.4% respectively whereas
significant decrement in the WBC’s count by 59.5% as compared with the control malignant group. Treatment of malignant rats with Boswellia carteri as pre/post doses caused suppression
of oxidative stress status as significant reduction in the levels of serum malondialdehyde (MDA)
and colonic tissue MDA and nitric oxide (NO), by about 64.5%, 66.7% and 49.9%, accompanied by increased levels of blood and tissue reduced glutathione (GSH) by 124.4% and 89.3%, with
supporting the enzyme activities of erythrocyte superoxide dismutase (SOD) and serum catalase
(CAT) by 25.8%, and 74.1% respectively when compared with the control malignant group (P<0.05). Significant improvement was also found in the levels of blood proteins and blood lipids profile in malignant rats by oral doses of the water extract when compared with the control malignant group. Further, serum tumor markers as alpha-fetoprotein (AFP),
carcinoembryonic antigen (CEA), cancer antigen-19.9 (CA-19.9), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and alkaline phosphatase (ALP) were reduced significantly by oral doses of the extract given before and after colon cancer induction by 68.1%, 26.1%, 48.8%, 37.4%, 61.1% and 13.9%, respectively as compared with malignant rats consumed the extract after colon cancer induction (P<0.05).