الفهرس 
IntroductionOnly 14 pages are availabe for public view
 |  | from | 107 |  |  |
| | | from | 107 | | |
Abstract
This study was carried out at Benha University, Veterinary Medicine College. It composed two experiments. The first one aimed to investigate the effects of administration Emblica officinals orally by gastric gavage tube for non-tumor bearing mice ” NTB- mice” on Survival rate and percentage, ascitic volume and cell count of tumor cells, Liver enzymes (AST and ALT) and blood antioxidant enzymes during experimental period. The second
experiment aimed to investigate the effects of administration Emblica officinals orally by gastric gavage tube for tumor bearing mice “TB- mice” on tumor growth response, Liver
enzymes (AST and ALT) and blood antioxidant enzymes during experimental period. A total number of 150 Australian female albino mice, 12-14 weeks old age and weighng 25-30 gm were used in the experimental investigation of this study. The animals
were fed on a constant ration throughout experimental period. In the first experiment, a total number of 60 of normal female mice were divided into equal three sub groups , the first (NTB- mice control) which were administered with 0.2 ml of normal saline only (NTBmice
control), the second (NTB- mice) which were treated with Emblica officinals orally by gastric gavage tube at a dose of 500 mg/Kg /every alternate day, the third (NTB- mice) which were treated with Emblica officinals orally by gastric gavage tube at a dose of 1250
mg/Kg /every alternate day. In the second experiment, a total number of 90 of female TBmice were divided into equal three sub groups, the first (NT- mice control) which were administered with 0.2 ml of normal saline only (NT- mice control), the second (NT- mice)
which were treated with Emblica officinals orally by gastric gavage tube at a dose of 500 mg/Kg /every alternate day, the third (NT- mice) which were treated with Emblica officinals orally by gastric gavage tube at a dose of 1250 mg/Kg /every alternate day. Data collections for the experiment treatments were Survival rate and percentage, ascitic volume and cell count of tumor cells, liver enzymes (AST and ALT) , alkaline
phosphatase, bilirubin , creatinine and antioxidants enzymes (reduced glutathione GSH,
superoxide dismutase SOD, and Catalase CAT). Results obtained could be summarized as follows: 1. Survive mice and percentage of survive tumor bearing mice was increased, whereas,
dead mice was decreased by increasing Emblica officinals dose during experimental period. were significantly attenuated directly by increasing Emblica officinals dose from 500 mg /kg as compared to saline treated group at 8, 15
and 23 day after injection of ascitic fluid.
3. Liver enzymes (AST and ALT) , serum bilirubin and alkaline phosphatase were
insignificantly changed for non-tumour bearing mice treatments due to different
dose of Emblica officinals during experimental period as compared to saline treated
group, while, they were significantly attenuated by Emblica officinals treatment during different intervals periods as compared to saline treatment mice for tumor bearing mice treatments .
4. Serum creatinine was no significant change for both tumor bearing mice treated with 500 mg/kg and non-tumor bearing mice groups which treated with different Emblica officinals dose of during experimental period as compared to saline treated group, while, the tumor bearing mice group which treated with Emblica officinals by 1250 mg/kg had significantly attenuated in serum creatinine at different intervals periods as compared to saline treatment mice.5. Blood reduced glutathione was significant elevation by treated with Emblica officinals of different doses at different me intervals except at 1st week for 500 mg /kg dose for non-tumor bearing mice , whereas, it was significantly elevated by different
Emblica officinals doses for tumor-bearing mice at different times of experiment. 6. Treatment of non-tumor bearing mice by Emblica officinals with different doses for 3 weeks resulted in significant elevation in serum SOD and Catalase at different time intervals except at 1st week for 500 mg dose, while, serum SOD and Catalase values were significantly decreased for tumor-bearing mice groups which treated with
different dose of Emblica officinals at different times.