الفهرس 
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Abstract
This study aimed to assess the outcome of mechanically ventilated COPD patients admitted in Respiratory intensive care unit ( RICU) in Ain Shams University hospitals in 2011 and the factors influencing it. This study included fifty mechanically ventilated COPD patients, 45 males (90%) and 5 females (10%) with a mean age of 62.8yrs ± 11.3. 24 patients (48%) were smokers, 23(46%) were ex-smoker while 3(6%) never smoked. Out of the fifty patients, 26 patients (52%) had co morbidities whereas 24 patients (48%) had none.
The higher mortality was found among patients with advanced age. The gender, smoking habits and co-morbidities of the patients didn’t account for any statistical difference between survivors and non survivors.
Hypoalbuminemia was associated with higher mortality among studied patients.The study reported that mortality was lower in patients who had no bacterial growth in their sputum culture. It was found that mortality rate was lower in patients who had successful weaning at first trial and who had no complications on mechanical ventilation but the mortality rate increased among patients who required several trials of weaning.
The mortality rate increased among COPD patients who had tracheostomy. The higher mortality could be attributed to presence of complications as VAP ARDS , hypokalaemia , hypoalbuminemia and repeated attempts of unsuccessful weaning.
Mechanical ventilation (MV) duration and the length of ICU stay were longer among non survivors. The mortality rate of COPD patients receiving mechanical ventilation was 28%.
There were no statistically significant correlations between arterial blood gases on admission and length of ICU stay among COPD patients requiring mechanical ventilation. There was no statistical significant difference between presence of co morbidities and length of ICU stay. This study recorded that there was significant correlation between mechanical ventilation duration and length of stay in ICU, when duration of mechanical ventilation increased that led to increase length of stay in ICU. from this study it can be concluded that several predictors can affect the outcome of COPD patients on mechanical ventilation (increasing the length of stay and mortality rate) These predictors were; age , hypoalbuminemia ,presence of resistant organisms in sputum culture ,failure of several trial of weaning , presence of VAP, ARDS ,when mechanically ventilated patients had tracheostomy and prolonged mechanical ventilation duration.