الفهرس 
Drugs acting directly on nucleic acidsOnly 14 pages are availabe for public view
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Abstract
A wide variety of thiazole derivatives with potential anticancer activity is known in the literature. The present study involves the design and synthesis of new thiazole derivatives that are structurally related to some known anticancer agents in an attempt to produce safe and effective anticancer compounds.
Forty four compounds were prepared via different synthetic routes, among them thirty five compounds are new. The preparation of the synthesized compounds was monitored by TLC, and structure elucidation was fulfilled based on elemental analyses (C, H, N), IR, 1H NMR, 13C NMR and mass spectroscopy.
Thirty two compounds were selected by the National Cancer Institute (NCI, USA) for in vitro anticancer assay against tumor cells in full NCI 60 cell panel. The compounds were tested at single dose of 10-5 M. The data is reported as a mean graph of the percent growth of treated cells. The results revealed that compounds 140b, 136b and 139a exhibited the lowest mean percentage growth against the full 60-cell line panel. Furthermore, compounds 130-132(a-c), 133a, 135-138(a) and 140,141(a) showed observed low cell growth promotion against Renal UO-31 cancer cell line with cell growth promotion varying from 52.72 to 64.52% Compounds 133a, 135-140(a) and 136,137(b) exhibited increased potency towards CNS SNB-75 cancer cell lines with growth percentages ranging from 56.53 to 69.22%. In addition, compounds 131c, 132,135(b), 136(a,c), 138a, 138-141(c) and 141a demonstrated increased the potency towards Non-Small Cell Lung HOP-92 with cell growth promotion varying from 59.05 to 69.98%.
Furthermore, assessment of toxicities, druglikeness, and drug score profiles are reported. Some of the synthesized compounds showed good docking scores with potential anticancer targets, chosen based on pharmacophore mapping of the established derivatives. Predicting potential side effects was also accomplished utilizing SePreSA server. These comparative computational studies were carried out for the synthesized compounds, to study the structure activity relationship, with the aim to determine which portions of the molecules are important for the observed or predicted activity.