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العنوان
Pharmacological studies on some medicinal plants /
المؤلف
El-Ashry, Eman Saleh Ibrahim.
هيئة الاعداد
باحث / ايمان صالح ابراهيم العشرى
مشرف / مجدى صلاح مصطفى عامر
مشرف / محمد حسن خيرى
مناقش / عبد العليم فؤاد عبد العليم
مناقش / محمد جبر السيد جبر
مناقش / مجدى صلاح مصطفى عامر
مناقش / محمد حسن خيرى
الموضوع
Green tea. Ginger. Diabetes. Anti-inflammatory. Analgesic. Antipyretic.
تاريخ النشر
2014.
عدد الصفحات
141 p. :
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
Veterinary (miscellaneous)
تاريخ الإجازة
11/2/2014
مكان الإجازة
جامعة المنصورة - كلية الطب البيطرى - الادوية
الفهرس
Only 14 pages are availabe for public view

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Abstract

This study was performed in Pharmacology Dept. Faculty of Veterinary. Medicine, Mansoura University:-
The first experiment was performed to investigate the effect of green tea extracts (either alcoholic or watery) on the levels of blood glucose, hepatic superoxide dismutase, glutathione peroxidase and reduced glutathione enzymes of diabetic rats. Forty adult male albino rats weighting (160 -200 g) were used and divided into 5 experimental groups: The first group was served as control group. The remaining groups (each of 8 rats): were injected (i.p) by streptozotocin (STZ) at 50 mg/kg b.wt to induce diabetes. The third diabetic group was treated with cidophage (500 mg/kg, orally).While, the fourth and fifth diabetic groups were treated with alcoholic and watery extracts of green tea (300 mg/kg b.wt, orally for each), respectively. All treatment were given daily for successive 4 weeks. The levels of blood glucose, superoxide dismutase, glutathione peroxidase and reduced glutathione were measured at 2 and 4 weeks after treatments of diabetic groups. The rats were sacrificed at the end of 4th week post treatment and the pancreas and the livers tissues were collected for histopathological studies.
The obtained results showed that the use of green tea extracts reduced the level of blood glucose of diabetic rats, and it caused a noticeable increase in the hepatic activity of superoxide dismutase reduced glutathione and glutathione peroxidase enzymes. Moreover, green tea extracts are capable of improving the impaired pancreas and liver of STZ diabetic animals.
The second experiment was conducted on 40 male mice for estimation of anti-inflammatory and analgesic activity and 16 rats for determination of antipyretic activity of ginger. All groups divided as follow: 1st group control +ve given 0.2 ml (i.p) physiological saline, 2nd group treated with 10 mg/kg b.wt (i.p) Indomethacin. While the third and fourth groups treated with alcoholic and aqueous extract of ginger (150 mg/kg b.wt .i.p) respectively. The obtained results showed that the ethanolic and watery extracts of ginger have variable anti-inflammatory, analgesic and antipyretic effects.
The third experiment studying the effect of each of green tea (50 mg/kg b.wt) and ginger extracts (25 mg/kg b.wt) on blood pressure and respiration in anaesthetize dogs (40 mg / kg I.V thiopental). It was observed that green tea and ginger extracts not produce any obvious effect on blood pressure. Meanwhile the rate of respiration was slightly increased.