الفهرس 
acknowledgmentOnly 14 pages are availabe for public view
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Abstract
Summary Current research aims to: -
Study and understand the effect of the magnetic field with intensity very low (3mT)
on total body fluids of mice injected with (Ehrlich tumor), as well as depressing the
osmotic fragility of the blood; blood viscosity; dielectric properties of hemoglobin tumor
growth; the relative weights and the survival time of mice. This work contains five
chapters and (141) of scientific references and a summary in English and another in
Arabic, and we will be Describe, in brief, the contents of this work
Chapter I:-
This chapter gives a general introduction to the interactions of electromagnetic
radiation with biophysical tissues and the effects caused by it on the tissue. Also reviews
the history of research in this field and the most important research, published in this field,
it also review gives types of magnetic radiation, and it briefly explains methods of
interaction between different kinds of magnetic field with living cells
Chapter II:-
This chapter reviews the definitions and explains the theoretical basis of the
electromagnetic properties of Radiology in general and especially magnetic radiation. This
chapter is divided into two sections the first section reviews the physical properties of red
blood cells. The second section gives an explanation of the biophysical properties that will
be studied in this research.
Chapter III:-
This chapter provides a discussion of previous studies and explains the techniques of
measurement used as a basis for this work. This chapter is divided into three sections. First
section reviews the materials used in the preparations for the experiment and the device
used in the irradiation. The second section explains injection method and the division of
experimental animals to different groups. Third section explains the method used to
measure: - blood viscosity; osmotic fragility of red blood cells; permittivity and
conductivity of Hemoglobin, tumor growth; the survival time of mice; and the relative
weight of mice.
Chapter IV:-
This chapter includes experimental data where this chapter has three sections. First
section displays the results and data obtained in measuring the intensity of the magnetic
field used in the irradiation.
The second section reviews the analysis graphics and data results that have been
obtained from the experiment conducted measurements after slaughtering rats irradiated In
this experiment, was to display data and curves osmotic pressure; viscosity and properties
dielectric (conductivity and permittivity) and showed statistical analysis on the
characteristics of dielectric that changes in osmotic pressure for groups of four given
Summary
- 61 -
changes the fact also that the changes that impurity in viscosity between the four
experiments given changes statistically significant (P <0.05) For each of the conductivity
and permittivity of hemoglobin rats irradiated and non-irradiated has also given significant
change where we found that the group injected tumor and exposed to radiation is top
groups in the values of each of the electrical conductivity and permittivity.
The third Section presents the analysis of data obtained from the study of the tumor
and follow-up stages of growth during the experiment measuring the size and measurement
of weight after the season at the end of the experiment and notes through the study of the
size and a comparison between the group injected, which was exposed to radiation and the
group that was not exposed with injected. tumor size in the irradiated group is smaller
compared with the beginning of the experiment, while the other group the size increased of
the tumor significantly its size at the beginning of the experiment. And also in line with
these experiments values of the relative weight to be calculated at the end of experiment
for both groups, we found that the geese relative to irradiated group smaller than the nonirradiated
group.
As for the survival time this part also graphically depicted shows a comparison
between the survival time of mice of the two groups bearing tumor and control group and
we found through this drawing that the life of the irradiated mice higher compared with the
group injected and non-irradiated.
Chapter V:-
This chapter provides a discussion of the results obtained from the experiments with
a summary of what we learned from these results, the appearance of several peaks in the
osmofragility differential curves indicates changes in the packing mechanisms between
adjacent molecules forming the cellular membrane. The shift of the main peak and CS
towards higher or lower concentrations of NaCl indicates changes in the membrane
permeability to water molecules. One may find from the osmofragility differential curves
the appearance of several peaks, changes in the values of Cs and WHmax for blood
samples from groups 1B ,2B and 3B as compared with control group A, which all indicate
changes of the membrane elasticity and permeability
Our results concerning the effect of EMF exposure on the erythrocytes viscosity
showed increase in viscosity of erythrocytes of mice bearing tumor compared to control.
where the value of viscosity of groups was 2.61for control group A, while for
experimental group 1B, 2B and 3B, was.2.99, 2.28, and 3.31 respectively. And the increase
in conductivity observed in our study reflects the permeability damage of the cell
membrane with the subsequent loss of ions, electrolytes and intracellular components.
The results indicate a strong dispersion in the β region for all the samples from all
groups studied. The dielectric dispersion in the β range (0.1-1 MHz) is mainly due to
protein and counter ion molecular relaxation. Moreover the results indicated that the values
of the σ for Hb molecule from exposed groups to the magnetic field (3mT) were higher
than control. One may conclude that the dose 3 mT may cause more damage. Since RBCs
membrane play an essential role in the blood flow rate, changes in its biophysical
properties will affect its capability for carrying on its metabolic functions since the RBCs
counts were changed after exposure of the animals to the magnetic field.
Summary
- 62 -
It is also clear that the exposure to EMF increase the survival time and inhibits tumor
growth of mice bearing Ehrlich tumor. This result confirms the anticancer activity of EMF
with intensity of 3mT, previous study on tumor growth inhibition using the same animal
model was reported. (129)
Mice exposed to EMF (3 mT, 50 Hz) showed tumor volume ratio of 1.93 and
inhibition ratio of tumor 75.22 % and increased life span of 101.09% with mean survival
time of 35.60 days. While sham exposed mice showed tumor volume ratio of 4.65 and
inhibition ratio of tumor after treatment 11.49 % and increased life span of 1.56% with
mean survival time of 12.60 days.