الفهرس 
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Abstract
The thesis is concerned with the analysis of some drugs acting on gastrointestinal tract through development of sensitive, precise and accurate methods for the determination of the investigated drugs either in the pure form, in their pharmaceutical formulations or in the presence of some drug degradation products with low cost depending on the availability of chemicals and equipments. The investigation includes usefulness of spectrophotometer and HPLC. These drugs include ranitidine hydrochloride, famotidine, omeprazole, pantoprazole sodium, tinidazole and doxycycline hydrochloride. The thesis consists of three main parts. Part I This part is concerned with the demonstration of chemical structure, physical and pharmacological properties of the studied drugs and also a theoretical basic background review on the previous methods of the assay of the cited drugs. Part II This part describes spectrophotometric methods and it is subdivided into following parts:
English summary
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Part II.A: This part enumerates the reagents and dyes used throughout the spectrophotometric methods, their molecular structures and their utilization as chromogens and also shows the concentration of their working solutions. Part II.B: This part describes spectrophotometric methods for the determination of ranitidine hydrochloride by two main methods. The first method demonstrates the nucleophilic substitution reactions of ranitidine with either 2,4-dinitrofluorobenzene, 4-chloro-7-nitrobenze-2-oxa-1,3-diazole accompanied with a kinetic study or 1,2-naphthoquinone sulphonate sodium salt. The reaction products were measured at λmax 420 nm, 468 nm and 488 nm, respectively. The second one is based on the determination of ranitidine HCl with bromatometric method using thymol blue, methylene blue and rhodamine B as dyes. The absorbances were measured at λmax 546 nm, 678 nm and 556 nm, respectively. The proposed methods were applied for determination of the cited drug in some pharmaceutical preparations. The obtained results were compared with those of the reference methods.