الفهرس 
INTRODUCTIONOnly 14 pages are availabe for public view
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Abstract
Hepatitis C virus (HCV) infection and its associated major complication, hepatocellular
carcinoma (HCC) are challenging health concerns in Egypt and worldwide. As a result of
the limited therapeutic effect, serious side effects and high cost of the currently available
drugs, there is a real need for an alternative and more effective medication to overcome
these serious diseases.
Benzofurans and their bioisosteres, benzimidazoles and indoles were remarkably reported
as anti-HCV and anticancer agents. A lot of compounds containing these heterocyclic
systems were shown to act against HCV and cancer through various mechanisms.
The present study targeted the design of novel hybrid derivatives having dual
pharmacological activity as anti-HCV and anticancer agents. Various hybrid derivatives
were synthesized to contain both an anti-HCV pharmacophore (benzofuran or
benzimidazole) attached to thiazolidinone or rhodanine rings at different positions through
linkers of various lengths) and anticancer pharmacophore (1,3-diaryl-1H-pyrazoles or
substituted isatins). Moreover, the newly synthesized derivatives were biologically
investigated for their anti-HCV and anticancer activities. In addition, a molecular modeling
study was carried out to select derivatives with the best binding affinities to be synthesized,
and also to explain the results of the biological investigation.
The present thesis comprises the following chapters:
Chapter I: Introduction
This chapter shows in brief some basic information about HCV, its molecular virology and
its relation to HCC. In addition, some previously reported benzofurans, benzimidazoles
and indoles together with their biological activities as anti-HCV and anticancer agents are
covered in this chapter, focusing on the recent reports.
Chapter II: Research Objectives
This chapter illustrates the aim of the present work and the rationale according to which
the newly synthesized compounds were designed.
Chapter III: Discussion
This chapter discusses the theoretical bases of the methods adopted for the synthesis of the
intermediates and final designed compounds with reference to the knowledge available in
the literature. It includes three parts:
Part 1:
It describes the preparation of the first intermediates 1-[1-(benzofuran-2-
yl)ethylideneamino]-3-substituted thioureas and 1-[1-(1H-benzimidazol-2-yl)ethylideneamino]-
3-substituted thioureas(2.1-2.9) through the reaction of 2-acetylbenzofuran or 2-
acetylbenzimidazole with the appropriately substituted thiosemicarbazide.