الفهرس 
HEPATOCELLULAR CARCINOMAOnly 14 pages are availabe for public view
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Abstract
Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide; the incidence of hepatocellular carcinoma has increased sharply in the last 10 years, with an especially high incidence in Egypt. Nutrition is thought to have a central role in the development of cancer; food intake imbalance is not by-itself cancer causing agent, but is a risk factor that fosters the occurrence of HCC. This study was conducted to identify some of the biochemical mediators/pathways implicated in HCC and to investigate the impact of unbalanced diets on HCC progression in mice. In this study, mice were randomly classified into two major groups: control group and HCC group. Each group was further divided into five subgroups according to the received diet: balanced diet (BD), high fat (HF),low fat (LF), high carbohydrate (HC), and low carbohydrate (LC) groups. Mice of both groups were maintained on the assigned diet for 10 weeks, whereas HCC induction started after the 2nd week in mice of HCC group. Early stage HCC was induced by intraperitoneal (i.p.) injection of diethylnitrosamine (DEN) 200 mg/kg as a single dose and after 2 weeks the mice were subjected to i.p. injection of thioacetamide (TAA) 100 mg/kg twice per week for four weeks. At the end of experiment (10 weeks), mice were weighed, sacrificed, and blood and liver samples were collected.