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Abstract The aim of this present study was to assess the hyperlipidemia improving profile of ice black tea as a nutriceutical approach to hyperlipidemia in rats rendered hyperlipidemic by long term feeding on highfat and high cholesterol diet To assess this aim we used albino rats which were divided into seven groups,each consists of ten rats as follows: GROUP I : Rats were fed on normal diet and received no drugs; kept as negative control.GROUP II : Rats were fed on high-fat diet and received no drugs; kept as positive control for all experimental groups. GROUP III : Rats were fed on normal diet and received ice BT after 30 days from the start of the experiment; kept as negative treated group. GROUP IV : Rats were fed on high-fat diet and received ice BT after 30 days from the start of the experiment; kept as positive treated group. GROUP V : Rats were fed on high-fat diet and received ice BT from the start of the experiment; kept as prophylactic group. GROUP VI : Rats were fed on high-fat diet and received atorvastatin after 30 days from the start of the experiment; kept as a standard treated group. GROUP VII: Rats were fed on high-fat diet and received EZE after 30 days from the start of the experiment; kept as standard treated group. Serum samples were collected on the 30th, 45th and 60th days from the start of the experiment and subjected for biochemical analysis. Tissue samples were taken on the last day of the experiment for histopathological examination. The following results were obtained: SUMMARY 91 1- In normal rats, Ice BT extract caused insignificant changes in serum total lipids concentration all over the period of the experiment; yet, its administration significantly decreased serum total lipid concentration in rats fed on high-fat diet 2- In normal rats, Ice BT extract caused insignificant changes in serum cholesterol concentration all over the period of the experiment; yet, its administration significantly decreased serum cholesterol concentration in rats fed on high-fat diet 3- In normal rats, Ice BT extract caused insignificant changes in serum TG concentration all over the period of the experiment; yet, its administration significantly decreased serum TG concentration in rats fed on high-fat diet 4- In normal rats, Ice BT extract caused insignificant changes in serum HDL-C concentration all over the period of the experiment; yet, its administration significantly increased serum HDL-C concentration in rats fed on high-fat diet 5- In normal rats, Ice BT extract caused insignificant changes in serum LDL-C concentration all over the period of the experiment; yet, its administration significantly decreased serum LDL-C concentration in rats fed on high-fat diet 6- In normal rats, Ice BT extract caused insignificant changes in serum VLDL-C concentration all over the period of the experiment; yet, its administration significantly decreased serum VLDL-C concentration in rats fed on high-fat diet 7- In normal rats, Ice BT extract caused insignificant changes in serum ALT concentration all over the period of the experiment; yet, its SUMMARY 92 administration significantly decreased serum ALT concentration in rats fed on high-fat diet 8- In normal rats, Ice BT extract caused insignificant changes in serum AST concentration all over the period of the experiment; yet, its administration significantly decreased serum AST concentration in rats fed on high-fat diet 9- In normal rats, Ice BT extract caused insignificant changes in serum urea concentration all over the period of the experiment; yet, its administration significantly decreased serum urea concentration in rats fed on high-fat diet 10- In normal rats, Ice BT extract caused insignificant changes in serum creatinine concentration all over the period of the experiment; yet, its administration significantly decreased serum creatinine concentration in rats fed on high-fat diet It could be concluded that ice BT has a good health impact in cases associated with hyperlipidemia. |