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Abstract
This study aimed to assess the effect of simvastatin on healing of
experimentally induced periapical lesions. 2.5 mg/ml and 5 mg/ml simvastatin
was injected through the root canals, in experimental group I and II,
respectively. The control group was injected with saline. After one week the
canals were obturated. The results showed that the use of simvastatin as
intracanal medication in cases of periapical lesions can downregulate
inflammation, promote periodontal repair and accelerate healing.