الفهرس 
Radiation and hypothalamic - Pituitary functionOnly 14 pages are availabe for public view
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Abstract
Radiation is known to induce {njury to the tissue e>.posed to radiation
and these effects reflect on its fimction (Duncan and Nias, /977). Many
studies have demonstrated a high incidence of anterior pituitary hormone
deficiencies occuring for many years after radiotherapy admimstered to
the hypothalamic-pituitary region.
Early studies suggested that the pituitary gland itself was finmd
resistant to the effects of radiotherapy (8100- 1000 c-Gy) and there was no
hypopituitarism. These results were not accurate because the endocrine
tests used were primitive and the subjects were observed for on(v a few
months after treatment.
Recently, Samoan eta/., (/982) showed that in patients irradiated for
head and neck tumour, the pituitary gland as well as the hypothalamus may
be susceptible to radiation induced damage.
The total dose of irradiation may not be the only factor which affects
the incidence of subsequent hypopittutarism, thefi’action size may also be
an important factor (Shalet eta/., /979).
Advances in radioimmunoassay techniques and the availability of Synthetic
hJpothalamic releasing factor ar;sesing the secretory reverse of pituitary
hormones now permit a more accurate assessment of their
deficiencies.
Aim of