الفهرس 
IntroductionOnly 14 pages are availabe for public view
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Abstract
Temporal lobe epilepsy (TLE) is the most prevalent cause of both focal and refractory seizures. Hippocampal sclerosis is the most common histological findings in temporal lobe epilepsy. A variety of imaging modalities have been used to evaluate seizure patients specialty those with temporal lobe origin, among these are magnetic resonance imaging (MRI), positron emission tomography(PET) and recently magnetic resonance spectroscopy (MRS). Proper localization of seizure focus is the main goal to properly manage these patients and determining whether subjected to medical or surgical intervention. Surgical removal of the focus eliminates or greatly reduces seizures in about 50 to 90% of patients with TLE who have concordant hippocampal atrophy. Mesial temporal sclerosis is the sole pathologic finding in 65% of temporal lobectomy specimens from adult patients with TLE. On magnetic resonance imaging, mesial temporal sclerosis displays hippocampal atrophy, signal intensity and structural distortion. However, a category of patients with TLE appear to have negative MR images and those patients with negative MRI may have difficulty in proper focus localization and if candid for surgery, may have poorer seizure control after hippocampectomy.