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Abstract Beta-thalassemias are a group of hereditary blood disorders characterized by abnormalities in the synthesis of the beta chains of hemoglobin resulting in variable phenotypes ranging from severe anemia to clinically asymptomatic individuals. The clinical picture of thalassemia major is characterized by growth retardation, pallor, jaundice, and skeletal changes resulting from expansion of the bone marrow. Individuals with thalassemia major usually present within the first two years of life with severe anemia, requiring regular red blood cell (RBCs) transfusions which leads to iron overload and its related complications including growth retardation and failure or delay of sexual maturation, involvement of the heart (dilated cardiomyopathy or rarely arrythmias), and liver (fibrosis and cirrhosis). Compliance with iron chelation therapy mainly influences frequency and severity of the iron overload-related complications. Patient with multi-transfused thalassemia major (TM) develop severe endocrine complications. Iron over load due to multiple transfusions is the main cause of such complications. The aim of this work was study parathyroid function in children with beta thalassemia major and its correlation with iron overload. |