الفهرس 
Systemic Lupus ErythematosusOnly 14 pages are availabe for public view
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Abstract
This study was designedto determine the difference inresistin levels intheserum ofpatientswithsystemiclupuserythematosus(SLE)and rheumatoid arthritis (RA) compared to a control group of apparent healthy persons. The aim extends to examine the relationship and possibleassociationsbetweenthelevelsofresistinanddifferentmarkers of disease activity, inflammation, renalfunction, lipidsand bone mineral densityinpatientswithSLEandRA,in ordertoassessthevalueof resistinasaspecificmarkerofinflammationinpatientswithSLEand RA.
Thisstudyincludedthreegroups:
Group (I):
Included30patientssufferingfrom SLEdefinedaccordingto the updatedAmericanCollegeofRheumatology(ACR)revisedcriteriafor the classification of systemic lupus erythematosus (SLE) (Hochberg,
1997).
They wereallfemales(100%)whoseagesrangedbetween19-62 years(meanof40.36±SD 10.55years) and disease durationranging between 1-25years (meanof9.73± SD6.78years).ThemeanBMIof thisgroupwas32.055±SD1.07kg/m2witharange from20.96-40kg/m2.
Group (II):
Included 30 patients suffering from RA defined according to the
AmericanCollegeofRheumatology(ACR)revisedcriteria(Arnettetal.,1988).
Theywereallfemales(100%)whoseagesrangedbetween20to 60 yearswith(meanof40.24±10.41years)anddiseasedurationranging
between6months-16years(meanof6.18±SD3.7years).Themean
BMIofthisgroupwas29.48±SD1.11kg/m2 witharangefrom22.3-
38.46 kg/m2.
Group (III)
A controlgroupincluding30apparenthealthyvolunteersmatched forageandsexwithother groups,they wereallfemales(100%).Their agesrangedbetween21-57years(mean38.07± SD11.12years). The meanBMIinthisgroupwas30.17±SD1.23kg/m2 witharangefrom
23.47-39.87kg/m2.
Allpatientsweresubjectedtofullhistory taking,fulldetailed clinicalexamination,laboratory assessment(ESR,CRP,renalfunction, urineexamination, lipidprofile, RF, ANA, anti-dsDNA, ACPA, C3and C4),X-ray both handsforRA patients,DEXAscanforbothSLEandRA patients,assessmentofdiseaseactivity accordingtoSLEDAIforSLE patientsandaccordingtoDAS28scoreforRApatient’sandassessment of radiologicaldamage for RApatientsusingLarsenscore.
Serum samplesfromallpatientsandcontrolsaretestedforresistinlevels. BMI wascalculatedfor patientsandcontrol.
Patientswiththefollowingconditions were excludedfromthe study:-
1.Pre existingdiseases causingnephritis,
2.Evidenceofmalignancy,
3.Concurrent infection,
4.Diabetesinpatientsandcontrol.
Theresultsofthisstudywereasfollows
Bystudyingthe resistinlevelsinsera of SLE,RAandcontrolitwas foundthat:
♦ThemeanresistinlevelsinseraofSLEpatientswas2.866ng/mlwith range 0.125- 12.52ng/ml.
♦WhilethemeanresistinlevelsinseraofRApatientswas3.002ng/ml
withrange 0.886- 8.964ng/ml
♦Inthecontrolgroupthemeanlevelsofserumresistinwas2.144ng/ml
withrange 0.134-7.767ng/ml.
Althougthe meanof serumresistinlevelsinSLE(2.866ng/ml) is greaterthancontrol(2.14ng/ml).Itwasinsignificant(p=.233).
The meanof serumlevelsof resistininRAis(3.002ng/ml) was greaterthancontrol(2.14ng/ml).ButIt wasinsignificant(p=.070) butclose tobe significant.
There wasnosignificantdifferencebetweenserumlevelsof resistinbetweenSLEandRAparients(p=0.098).
The comparisonbetweenthe resistinlevelsof the previousthree
groupswasnotstatisticallysignificantwhere p˃0.05.
AsregardSLE:
The effectof diseasedurationonserumresistinlevelsinSLEwere insignificantcorrelations(p>0.05).
Alllaboratoryparametershadinsignificantcorrelationswithserum resistinlevelsexcepttheplateletsthathadaninverse significant correlation(p=0.022). There isinsignificantcorrelationbetween
serumlevelsof resistinandSLEDAI (p=0.180).
Nosignificantcorrelationwasfoundbetweendailydoseofsteroid, antimalarial,azathioprine orcyclophosphamideandserum resistin levels.
TheeffectofT-scoreHip,T-scoreVertebraeandVitaminDon serum resistinlevelsinSLEwereinsignificantcorrelations (p>0.05).
AsregardRA:
The effectof diseasedurationonserumresistinlevelsinRA were insignificantcorrelations(p>0.05).
Alllaboratoryparametershadinsignificantcorrelationswithserum resistinlevels(p>0.05).
There was no significant correlation between weekly dose of methotrexate,daily dose ofanti-malarialandadalimumabtherapy andserumResistin.
The effectof T-scoreHip,T-score Vertebrae andVitaminDon serumresistinlevelsinRAwere insignificantcorrelations (p>0.05).
Thereisinsignificantcorrelationbetweenserumlevelsofresistin andDAS 28(p=0.207).
No significant correlation between serumlevels of resistin and
Larsenscore (p=0.735).