الفهرس 
HAEMOLYTIC ANAEMIA DUE TO CORPUSCULAR DEFECTSOnly 14 pages are availabe for public view
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Abstract
Introduction - 1
INTRODUCTION
Anaemia creates a public health problem. In developing countries, it is responsible for a great
deal of ill health, lack of energy and productivity and also for deaths in childhood (Khalifa,
1981).
In these countries, may factors interact to produce anaemia such as: low income, dietetic
deficiency, infection, large family size, parasitic infestations, all contribute to the severity
of anaemia (Awwaad et al.,
1973).
Nutritional anaemia due to deficiency of iron is the most common from of anaemia among Egyptian
children. Also Folic acid deficiency anaemia has been described specially in association with
protein energy malnutrition (Barakate, 1977).
In Egypt, 13-thalassaemia is the most common chronic haemolytic anaemia, and the incidence of
the heterozygous form in the normal population was reported to be 1.3% (Sabry, 1973). However,
other forms of chronic haemolytic anaemia are reported specially including Sickle anaemia, and
its incidence of carrier rate was determined to affect
14% of school children tested by Khalifa et al in 1990.
The frequency of deletional a-thalassaemia was estimated by Novelletto et al (1989) to be 0.08
among new-born random samples with no a determinants found.
Introduction- 2
The reported prevalence of glucose 6 phosphate dehydrogenase (Gupd) deficiency in Egyptian
population varies between 7.5-14.5% in lower Egypt Compared to 3% in upper Egypt. Among Gtipd
deficient subjects, it was reported that females account for 9.9% (Khalifa, 1981 ). However,
other forms of acute haemolytic anaemias are reported specially including haemolytic
disease of newborn and its incidence in Egyptian children has not been widely studied.
Hypoplastic anaemia whether congenital or acquired is a serious disease. The prevalence
among Egyptian children has not been widely studied Khalifa et al., in 1993 reported that
aplastic anaemia constituted
5% of all chronic anaemic patients referred to the Paediatric
Haematology/Oncology Clinic of Ain Shams University.
A1HA as a form of anaemia constituted 1. 7% of chronic anaemic patients with a relative
frequency of 1.7 per 100,000 clienteles of out patient clinir in the children’s Hospital, Ain
Shams University (Khalifa et al., 1993).
The most common cause of Coagulation disorders is haemophilias and Von Wiilebrand disease
(Blanchette e;. al., 1991). EL Shinnawi in
1984, reponed that the rate of haemophilia A in Egypt was 67%, haemophilia B was 3.3”
and VWD was 7.7% of all bleeding disorders.
Introduction- 3
ITP as a cause of platelet disorder was studied by Khalifa et ai in 1993 and the reported
incidence was 40% of cases with haemorrhagic disorders attending the Haematology
/Oncology clinic, Child rr.t’s Hospital, Ain Shams University.