الفهرس 
Review of LiteratureOnly 14 pages are availabe for public view
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Abstract
Introduction and Aim of the study
Introduction
Imraamniotic infection is a serious complication of premature rupture of the membranes and
so early detection of intra-amniotic infection is essential. Cinical and laboratory signs of
infection such as fever. leucocytosis and elevated (-reactive protein (CRP) are not very accurate
and may be delayed by 24 hours to 36 hours after the onset of the infection. We need a test
which is capable of identifj•ing intra amniotic infection soon after it occurs. (Romero et
all991).
Histological chorioamnionitis has been identified in 10-18 % of women with term deliveries .
Definitive diagnosis of histological chorioamnionitis is only possible at present by histological
analysis of the placenta after delivery (:\-li ller et all990).
.-\dequate diagnostic methods to premit the precise diagnosis of histological chorioamnionitis
as early and efficiently as poss:bl should be developed to ensure favorable outcome
of pregnane: (Shimoya et al 1997).
Some c;1okines such as interleukin -1 (IL-l), tumor necr’”’’ factor-a C r-a), interleukin- 6
(IL-6) and inter!eukin-8 (IL-8). h’e been shown to be useful for the detection and monitoring
ofvar’,•·., human intlammatory diseases. Similar analyses have been applic·.. diagnose
intraamniotic infection by titering cytokine level’ amniotic tluid (Romero et all991).
Introduction and Aim of the study
2
Inter!eukin-8 (IL-8), a 72-amino acid peptide, is produced by many cells, including
macrophages and neutrophils, and cells of the decidua, amnion and chorion. IL-8 has been shown
to be increased in amniotic fluid in cases of intra-amniotic infection (Trautman eta!
1992).