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العنوان
Chemistry and Biological Studies on the Effect of Some Vital Metal Ions on the Efficiency of some Pharmaceutical Compounds
المؤلف
Mahmoud, Sameh Abo Taleb
هيئة الاعداد
باحث / سامح أبو طالب محمود
مشرف / أ.د. منير زكى سعد
مشرف / د. محمد يسرى السيد
مشرف / د. سامى محمود المغربل
الموضوع
Vital Metal Ions Pharmaceutical Compounds
تاريخ النشر
2014
عدد الصفحات
xi,223
اللغة
الإنجليزية
الدرجة
ماجستير
التخصص
الكيمياء
تاريخ الإجازة
1/1/2014
مكان الإجازة
جامعة الزقازيق - كلية العلوم - الكيمياء
الفهرس
Only 14 pages are availabe for public view

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Abstract

Nalidixic acid, sulfadoxine, vitamin A and lisinopril compounds have a great biological, industrial and coordination applications. Most of their metal complexes have antibacterial and antifungal effects. The present work was studied the spectroscopic, stability and related thermodynamic parameters, structural, thermal, molar conductivity and biological properties of the above ligands with selected metal ions such as Ca(II), Mg(II), Zn(II), VO(II) and Fe(III).
The used theoretical concepts and experimental techniques were discussed. The outcome of the results can be summarized as the following:
The solid complexes of nalidixic acid, sulfadoxine, vitamin A and lisinopril have been prepared and characterized by IR, UV-vis, elemental analysis CHN and 1H-NMR. The outcome of the results is:
Nalidixic acid, sulfadoxine, vitamin A and lisinopril react with Ca(II), Mg(II), Zn(II), VO(II) and Fe(III) by molar ratio (1:1), which supported by elemental analysis.
The IR and UV-vis spectra of the solid complexes indicate that nalidixic acid behaves as a bidentate ligand coordinated to the metal ions via one carboxylate oxygen atom and the oxygen atom of the pyridine carbonyl group, sulfadoxine behaves as a bidentate feature coordinated to the metal ions via (C=N) and (S=O) groups, vitamin A behaves as monodentate ligand coordinate to the metal ions via the deprotonated hydroxyl oxygen atom finally lisinopril behaves as a monodentate feature via one carboxylate oxygen atom.